尿苷-5-二磷酸二钠盐
中文名称:
尿苷-5-二磷酸二钠盐
中文同义词:
尿苷-5-二磷酸二钠盐;尿苷-5′-二磷酸二钠盐，水合;尿苷-5-二磷酸二钠盐 1KG;焦磷酸尿苷钠盐,二磷酸尿苷二钠;尿苷-5-二磷酸 二钠盐 水合物;尿苷-5-二磷酸钠盐(UDP)(水合物);尿嘧啶-5-二磷酸二钠;5-二磷酸尿苷二钠
英文名称:
Uridine-5-diphosphoglucose disodium salt
英文同义词:
UDP 2NA;URIDINE 5-DIPHOSPHATE DISODIUM SALT;URIDINE 5-DIPHOSPHORIC ACID DISODIUM SALT;Uridine 5-diphosphate disodiu salt;Diquafosol Impurity 2(UDP Sodium Salt);5-UDP-Na2;Uridine 5-(trihydrogen diphosphate), disodium salt;UDP(URIDINE-5-DIPHOSPHATE)
CAS号:
27821-45-0
分子式:
C15H24N2Na2O18P2
分子量:
628.28
EINECS号:
248-678-9
相关类别:
核苷，核苷酸，寡核苷酸;化合物：原料药;核酸;生化试剂;医药中间体;核酸类;植物激素及核酸类;Material;其他生化试剂;中间体;精细化工;生化试剂-植物激素及核酸类;分析试剂标准品;杂质对照品;Pharmaceutical;二磷酸核苷;化工中间体
Mol文件:
27821-45-0.mol
储存条件
-20°C
形态
Powder
颜色
White to Off-white
水溶解性
Slightly soluble in water.
敏感性
Moisture Sensitive
BRN
8817400
InChIKey
KWDGQJWFEYTPBN-IBOJMDDDSA-L
CAS 数据库
27821-45-0(CAS DataBase Reference)
用途
尿苷-5-二磷酸二钠盐为有机金属化合物，可用作生化试剂，是P2Y6受体激动剂和GPR105受体抑制剂。
应用
尿苷-5-二磷酸二钠盐可用作生化试剂，P2Y 受体激动剂。
生物活性
Uridine-5-diphosphate (UDP) disodium salt 是一种有效的、选择性的 P2Y6 receptor 的天然激动剂，其EC50值为300 nM，pEC50值为 6.52。Uridine-5-diphosphate (UDP) disodium salt 也是 P2Y14 receptor 的拮抗剂，pEC50值为 7.28。
靶点
Target Value
P2Y 14 receptor
(Cell-free assay) 7.28(pEC50)
P2Y 6 receptor
(Cell-free assay) 300 nM(EC50)
P2Y 6 receptor
(Cell-free assay) 6.52(pEC50)
Target
Value
P2Y 14 receptor
(Cell-free assay)
7.28(pEC50)
P2Y 6 receptor
(Cell-free assay)
300 nM(EC50)
P2Y 6 receptor
(Cell-free assay)
6.52(pEC50)
体外研究
Uridine-5-diphosphate disodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression.
Uridine-5-diphosphate disodium salt (100 μM; 3 hours) induces chemokine expression in microglia.
Uridine-5-diphosphate disodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h.
Uridine-5-diphosphate disodium salt (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level.
Uridine-5-diphosphate disodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia.
Uridine-5-diphosphate disodium salt is a competitive antagonist at the human P2Y 14 receptor ( pEC 50 =7.28) but not rat P2Y 14 receptor.
UDP-glucose (UDPG; HY-N7032) is a potent P2Y 14 agonist.
RT-PCR
Cell Line: Primary microglia
Concentration: 100 μM
Incubation Time: For 15 min
Result: Significantly induced microglial CCL2 and CCL3 mRNA expression.
Cell Line:
Primary microglia
Concentration:
100 μM
Incubation Time:
For 15 min
Result:
Significantly induced microglial CCL2 and CCL3 mRNA expression.
危险品标志
Xi
危险类别码
36/37/38
安全说明
26-36
WGK Germany
3
F
10-21
海关编码
29349990
