中文同义词:
原人参三醇10MM*1ML (IN DMSO);原人参三醇10MM*1ML (IN DMSO)标准品;(S型)原人参三醇;20(S)-原人参三醇(PPT);原人参三醇(S);20 (S)-原人参三醇, >98%;20(S)-原人参三醇
英文同义词:
(20S)-Protopanaxatriol, >98%;20(S)-Protopanaxatriol 34080-08-5;PROTOPANAXTRIOL;PROTOPANAXADIOL(RG);Protopanaxtriol ,98%;20(S)-Protopanaxtriol(PPT);20(S)-Protopanaxtriol;(20S)-5α-Dammar-24-ene-3β,6α,12β,20-tetrol
相关类别:
优势产品;分析试剂标准品;对照品;标准品;小分子抑制剂，天然产物;主打产品;植物提取物;Ginseng series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;小分子抑制剂;Inhibitors;标准品-中药标准品;标准品 -中药标准品;三萜;中药对照品
沸点
590.0±50.0 °C(Predicted)
酸度系数(pKa)
14.73±0.70(Predicted)
生物活性
(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT)是人参皂苷中具有神经保护活性的代谢物。它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体，可调节内皮细胞功能。
靶点
Glucocorticoid receptor, Oestrogen receptor, LXRα
体外研究
(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (g-PPT) increases [Ca 2+ ] i with an EC 50 of 482 nM in HUVECs. (20S)-Protopanaxatriol (1 µM) elevates NO production via ERβ. (20S)-Protopanaxatriol (PPT) inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene.
化学性质
白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。
用途
用于含量测定/鉴定/药理实验等。
药理药效:原人参三醇型皂苷可以体外协同抗原负载诱导小鼠骨髓细胞的树突状细胞成熟，发挥对肿瘤细胞的特异细胞毒作用；其次，PPT型皂苷注射液能明显改善大脑中动脉阻塞(MCAO)大鼠的偏瘫体征、缩小脑内梗死面积、缓解脑水肿症状。
用途
(20S)-原人参三醇是人参皂苷的代谢产物。
