中文同义词:
4-二甲氧基肉桂酸;3,4-二甲氧基苯乙烯酸;3,4-二甲氧基肉酸酸;3,4-二甲氧基肉桂酸(CAS号:2316-26-9);3,4-二甲氧基苯丙烯酸/3,4-二甲氧基肉桂酸;咖啡酸二甲醚;3,4-二甲氧基肉桂酸(标准品);4-二甲氧基苯丙烯酸
英文名称:
3,4-Dimethoxycinnamic acid
英文同义词:
RARECHEM BK HC T253;TIMTEC-BB SBB005722;OTAVA-BB BB0107620014;(2E)-3-(3,4-Dimethoxyphenyl)-2-propenoic acid;3,4-Dimethoxycinnamic acid 98%;Caffeic acid dimethyl ether;3,4-DIMETHOXYCINNAMIC ACID 99% PREDOMINANTLY TRANS ISOMER;3,4-DiMethoxycinnaMic acid, 99% 5GR
相关类别:
常规有机化工类;有机中间体;芳烃;有机合成中间体;有机砌块;多奈哌齐中间体;医药原料;植物提取物;通用试剂;医药中间体;羧酸;Aromatic Cinnamic Acids, Esters and Derivatives;Cinnamic acid;Organic acids;Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;对照品;化工中间体;化工原料;苯丙素;化工中间体工业原料;化工中间体
沸点
267.4°C (rough estimate)
密度
1.0627 (rough estimate)
溶解度
Solubility in hot methanol, very faint turbidity. Soluble in dichloromethane, chloroform.
酸度系数(pKa)
4.53±0.10(Predicted)
颜色
Slightly yellow to light beige
InChIKey
HJBWJAPEBGSQPR-GQCTYLIASA-N
CAS 数据库
2316-26-9(CAS DataBase Reference)
NIST化学物质信息
3,4-Dimethoxycinnamic acid(2316-26-9)
生物活性
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) 是从 Securidaca inappendiculata 中提取和纯化的单体。3,4-Dimethoxycinnamic acid 通过 ROS 介导的信号途径对 L-02 细胞发挥抗凋亡作用。
体外研究
3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells.
3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22 phox in L-02 cells.
3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells.
3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner.
