盐酸地匹福林

中文名称:

盐酸地匹福林

中文同义词:

盐酸地匹福林 [64019-93-8];4-(1-羟基-2-(甲基氨基)乙基)-1,2-苯二醇二特戊酸酯盐酸盐;盐酸地匹福林;盐酸地匹福林 EP标准品;盐酸二维弗林;5-羟基色氨酸对照品

英文名称:

Dipivefrin hydrochloride

英文同义词:

dipivalylepinephrinehydrochloride;dipivefrinehydrochloride;dipivefrinhydrochloride;hydrochloride,(+-)-este;propanoicacid,2,2-dimethyl-,4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene;Progate;Propanoic acid,2,2-diMethyl-, 1,1-[4-[1-hydroxy-2-(MethylaMino)ethyl]-1,2-phenylene] ester,hydrochloride (1:1);DIPIVEFRIN HYDROCHLORIDE (200 MG)

CAS号:

64019-93-8

分子式:

C19H30ClNO5

分子量:

387.8982

EINECS号:

264-609-5

相关类别:

小分子抑制剂;中药对照品;标准品;盐酸地匹福林（标准品）;API

Mol文件:

64019-93-8.mol

熔点

158-159°

溶解度

Freely soluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent) and in methylene chloride.

形态

neat

酸度系数(pKa)

8.40(at 25℃)

生物活性

Dipivefrin hydrochloride (Dipivefrine hydrochloride) 是一种抗青光眼前体药物，通过角膜中的酯酶水解为其活性化合物肾上腺素。

体内研究

Dipivefrin hydrochloride (0.3-10 μg/kg; i.p.;) induces enhancement of memory involves central beta- but not alpha-adrenergic mechanisms. Animal Model: Male 60-day-old CFW mice (23-28 g) Dosage: 0.3 μg/kg, 1.0 μg/kg, 3.0 μg/kg, 10 μg/kg Administration: Intraperitoneal injection; post-training Result: Significantly enhanced retention of both inhibitory avoidance and Y-maze discrimination tasks in a dose-dependent manner.

Animal Model:

Male 60-day-old CFW mice (23-28 g)

Dosage:

0.3 μg/kg, 1.0 μg/kg, 3.0 μg/kg, 10 μg/kg

Administration:

Intraperitoneal injection; post-training

Result:

Significantly enhanced retention of both inhibitory avoidance and Y-maze discrimination tasks in a dose-dependent manner.

用途

降眼压药，用于治疗青光眼。

危险品运输编号

UN 2811 6.1 / PGIII