中文名称:
2-(3,4二羟基苯基)-5,7-二羟基-4-氧代-4H-1-苯并吡喃-3-基-BETA-D-吡喃葡糖苷酸
中文同义词:
槲皮素3-O-葡萄糖酸苷;槲皮素-3-葡萄糖醛酸苷;槲皮素-3-O-Β-D-吡喃葡糖苷酸;槲皮素-3-O-葡萄糖醛酸苷;槲皮素 3-O-Β-D-葡萄糖苷酸;槲皮素-3-0葡萄糖醛酸苷;槲皮黄酮 3-O-Β-D-葡萄糖苷酸;槲皮素 3-O-Β-D-葡萄糖醛酸苷
英文名称:
QUERCETIN-3-O-GLUCURONIDE
英文同义词:
3,3′,4′,5,7-Pentahydroxyflavone 3-glucuronide;Quercetol 3-O-glucuronide;Quercetol glucuronide;Quercetin 3-glucuronide ,>=99%;Quercetin 3-D-glucuronide;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl β-D-Glucopyranosiduronic Acid;Mikwelianin;Miquelianin
相关类别:
对照品;标准品-对照品;对照品;植物提取物;对照品、标准品、植物单体;对照品-中药对照品;标准品 -中药标准品;Miscellaneous Natural Products;标准品，对照品
沸点
927.8±65.0 °C(Predicted)
密度
1.96±0.1 g/cm3(Predicted)
酸度系数(pKa)
2.76±0.70(Predicted)
生物活性
Miquelianin (Quercetin 3-O-glucuronide)是槲皮素和一种天然类黄酮的代谢产物。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
Miquelianin shows an antioxidant effect in human plasma. At 50 μM, miquelianin suppresses the consumption of the three antioxidants lycopene, β-carotene and α-tocopherol significantly. In vitro studies indicate that miquelianin is able to reach the central nervous system from the small intestine. Miquelianin significantly reduces the generation of β-amyloid (Aβ) peptides by primary neuron cultures generated from the Tg2576 AD mouse model. It is also capable of interfering with the initial protein-protein interaction of Aβ1–40 and Aβ1–42 that is necessary for the formation of neurotoxic oligomeric Aβ species. Treatment with 0.1 μM miquelianin suppresses ROS generation, cAMP and RAS activation, phosphorylation of ERK1/2 and the expression of HMOX1, MMP2, and MMP9 genes. Miquelianin suppresses invasion of MDA-MB-231 breast cancer cells and MMP-9 induction, and inhibits the binding of [ 3 H]-NA to b2-AR. Miquelianin may function to suppress invasion of breast cancer cells by controlling b2-adrenergic signaling, and may be a dietary chemopreventive factor for stress-related breast cancer.
体内研究
Miquelianin treatment, compared to vehicle-control treatment, significantly improves AD-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation. A flavonoid fraction obtained from a crude extract of Hypericum perforatum (St. Johns wort) is remarkably active in the forced swimming test. Miquelianin is one of the compound separated from the fraction.
化学性质
棕色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于翻白叶，杠板归，春柴胡。
