七叶皂苷D

中文名称:

七叶皂苷D

中文同义词:

七叶皂苷D;七叶皂苷 IIB

英文名称:

ESCIN IIB

英文同义词:

AESCIN IIB;ESCIN IIB;06035642G6;b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-;β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-

CAS号:

158800-83-0

分子式:

C54H84O23

分子量:

1101.23

EINECS号:

相关类别:

标准品;对照品;中药对照品;植物提取物;标准品 -中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

158800-83-0.mol

沸点 

1111.9±65.0 °C(Predicted)

密度 

1.45±0.1 g/cm3 (20 ºC 760 Torr)

酸度系数(pKa)

2.63±0.70(Predicted)

生物活性

Escin IIb 是从七叶树种子七叶树中分离出来的，对动物急性炎症有积极作用。Escin IIb 对乙醇诱导的胃粘膜损伤有明显的保护作用。

体内研究

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibit the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didnt. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest. Escin IIb (10-50 mg/kg; p.o.) potently inhibits ethanol-induced gastric mucosal lesions. Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats) Dosage: P.o. Administration: 10-50 mg/kg Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats.

Animal Model:

Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)

Dosage:

P.o.

Administration:

10-50 mg/kg

Result:

Showed a potent protective effect against ethanol-induced gastric lesions in rats.