环黄芪醇

中文名称:

环黄芪醇

中文同义词:

三萜环黄氏醇;环黄芪醇;环黄芪宁;CYCLOASTRAGENOL 环黄芪醇;环黄芪醇(三萜环黄氏醇);环黄芪醇,CYCLOASTRAGENOL;环黄芪醇, >98%;环黄芪醇对照品,

英文名称:

cycloastragenol

英文同义词:

cycloastragenol;(3b,5ξ,6a,9ξ,10ξ,16b,17ξ,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;(3beta,6alpha,16beta,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;(3b,6a,16b,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;Cyclogalagenin;Cyclogalegenin;Cyclogalegigenin;Cyclogalgeginin

CAS号:

84605-18-5

分子式:

C30H50O5

分子量:

490.71

EINECS号:

 

相关类别:

优势产品;医药原料;植提标准品;对照品;中药对照品;标准品;对照品,标准品;植物提取物;chemical reagent;植物成分单体;分析试剂标准品;原料;标准品-中药标准品;有机原料;标准品 -中药标准品;分析试剂-标准品;标准品，对照品;分析试剂标准品;palnt extract;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

84605-18-5.mol

 

 

沸点 

617.2±55.0 °C(Predicted)

密度 

1.20

酸度系数(pKa)

14.57±0.29(Predicted)

生物活性

Cycloastragenol 是一种天然的四环三萜类化合物，在筛选黄芪提取物时鉴定出具有抗衰老活性。Cycloastragenol 是一种有效的端粒酶 (telomerase) 激活剂。Cycloastragenol 还具有其他药理作用，包括抗炎和抗氧化特性。

靶点

Target Value telomerase ()

Target

Value

telomerase ()

 

体外研究

Cycloastragenol (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures. Cycloastragenol (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type.Cycloastragenol (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression. Cell Viability Assay Cell Line: HEK cells Concentration: 1 µM, 3 µM, 10 µM Incubation Time: 3-6 days Result: Doubled the cell growth at 6 days. Western Blot Analysis Cell Line: Neuronal cells Concentration: 0-3 µM Incubation Time: 5 mins, 15 mins, 30 mins, 90 mins Result: Suggested that CAG induces CREB activation in neuronal cells. Western Blot Analysis Cell Line: Neuronal cells Concentration: 0-3 µM Incubation Time: 6-48 hours Result: Increased tert, bcl2 mRNA expression.

Cell Line:

HEK cells

Concentration:

1 µM, 3 µM, 10 µM

Incubation Time:

3-6 days

Result:

Doubled the cell growth at 6 days.

Cell Line:

Neuronal cells

Concentration:

0-3 µM

Incubation Time:

5 mins, 15 mins, 30 mins, 90 mins

Result:

Suggested that CAG induces CREB activation in neuronal cells.

Cell Line:

Neuronal cells

Concentration:

0-3 µM

Incubation Time:

6-48 hours

Result:

Increased tert, bcl2 mRNA expression.

化学性质 

来源于豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var. mongholicus （Bge.）Hsiao干燥根

用途 

用于含量测定/鉴定/药理实验等。