异荭草素

中文名称:

异荭草素

中文同义词:

异荭草素;异红草素;木犀草素-6-C-葡萄糖苷(异荭草苷);异荭草苷(异荭草素,异荭草苷 ,异荭草素);木犀草素-6-C-葡萄糖苷;LUTEOLIN-6-C-GLUCOSIDE 异荭草苷;异荭草素,异荭草苷 ,异荭草素;异荭草素, 来源于荭草

英文名称:

HOMOORIENTIN

英文同义词:

2-(3,4-Dihydroxyphenyl)-6-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one;6-(β-D-Glucopyranosyl)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;Isoorientin/HoMoorientin;lespecapittoside;2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one;2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]chromone;HoMoorientin, froM PolygonuM orientale;IsoorientinI

CAS号:

4261-42-1

分子式:

C21H20O11

分子量:

448.38

EINECS号:

相关类别:

中药对照品;标准品;分析标准品;高纯试剂;对照品;植物提取物;Tetra-substituted Flavones;chemical reagent;pharmaceutical intermediate;植提标准品;中药标准品;异荭草苷;分析对照品;细胞生物学试剂;标准品-中药标准品;标准品 -中药标准品;分析试剂-对照品;标准品，对照品;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

4261-42-1.mol

熔点 

245-246°C

沸点 

856.7±65.0 °C(Predicted)

密度 

1.759±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

methanol: soluble5mg/mL, clear, colorless to yellow

酸度系数(pKa)

5.90±0.40(Predicted)

形态

powder

颜色

yellow

InChIKey

ODBRNZZJSYPIDI-VJXVFPJBSA-N

生物活性

Isoorientin是一种有效的 COX-2 抑制剂，IC50 值为 39 μM。

靶点

COX-2 39 μM (IC 50 )

COX-2 39 μM (IC 50 )

体外研究

Isoorientin is a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. PANC-1 and PATU-8988 cells are grown for 24 hours in the presence of Isoorientin (0, 20, 40, 80, and 160 μM), and a CCK8 solution is added. The cell viability decreases significantly at the concentrations of 20, 40, 80, and 160 μM. After the cells are cultured with Isoorientin (0, 20, 40, 80, and 160 μM for PANC-1; 0, 20, 40, 80, 160, and 320 μM for PATU-8988) for 24 hours, the expression of p-AMPK and AMPK is assessed by Western blotting. After the Isoorientin treatment, the p-AMPK expression is increased. Then, in the shRNA group, the concentration of 80 μM is used to detect the effects of Isoorientin. The expression levels of AMPK and p-AMPK are much lower in the shRNA group than in the wild-type PC cells (WT) and the group that is transfected with a negative control lentivirus (NC).

体内研究

Animals treated with Isoorientin at 10 mg/kg and 20 mg/kg body weight have a statistically significant reduction in paw edema, with a mean peak thickness of 1.19±0.05 mm and 1.08±0.04 mm, respectively. This indicated that Isoorientin significantly attenuates paw edema compared with the control group.

化学性质 

黄色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于竹叶，夏枯草，石竹。

用途 

异荭草素具有抗心肌缺血的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:保肝作用，抗病毒活性，抗过氧化作用，解焦虑作用。

安全说明 

24/25

WGK Germany 

3

海关编码 

29389090