诃子林鞣酸

中文名称:

诃子林鞣酸

中文同义词:

诃子林鞣酸;诃子林鞣酸(标准品);柯黎勒酸;诃子林鞣酸对照品

英文名称:

CHEBULINIC ACID

英文同义词:

CHEBULINIC ACID;NSC69862;CHEBULINIC ACID(SH);Eutannin;β-D-Glucopyranose, 1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid;b-D-Glucopyranose,1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 22:41-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioicacid;Chebulinic acid >=85% (LC/MS-ELSD);CHEBULINIC ACID USP/EP/BP

CAS号:

18942-26-2

分子式:

C41H32O27

分子量:

956.68

EINECS号:

相关类别:

植提;植提标准品;植物提取物;对照品;标准品 -中药标准品;标准品，对照品;对照品;标准品-对照品

Mol文件:

18942-26-2.mol

沸点 

1460.0±65.0 °C(Predicted)

密度 

2.04

储存条件 

-20°C

酸度系数(pKa)

4.14±0.10(Predicted)

生物活性

Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂，也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。

靶点

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]

体外研究

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

化学性质 

白色结晶粉末。

用途 

用于含量测定/鉴定/药理实验等。

WGK Germany 

3