刺五加苷 C3

中文名称:

刺五加苷 C3

中文同义词:

刺五加苷 C3;刺五加皂苷C3

英文名称:

Ciwujianoside C3

英文同义词:

Ciwujianoside C3;Olean-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (3β)-

CAS号:

114906-74-0

分子式:

C53H86O21

分子量:

1059.24

EINECS号:

相关类别:

标准品;标准品

Mol文件:

Mol File

密度 

1.43±0.1 g/cm3(Predicted)

酸度系数(pKa)

12.50±0.70(Predicted)

生物活性

Ciwujianoside C3 是一种具有口服活性并可以穿透血脑屏障的化合物，分离于刺五加的叶子。 Ciwujianoside C3 具有抗炎作用，并可以增强小鼠个体的识别记忆力。

体外研究

Cell Viability Assay Cell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Has no effect on cell cytotoxicity and inhibits NO production Western Blot Analysis Cell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Decreases p-ERK and p-JNK expression. RT-PCR Cell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner.

Cell Line:

RAW 264.7 cells

Concentration:

10 µM, 20 µM and 40 µM

Incubation Time:

24 hours

Result:

Has no effect on cell cytotoxicity and inhibits NO production

Cell Line:

RAW 264.7 cells

Concentration:

10 µM, 20 µM and 40 µM

Incubation Time:

24 hours

Result:

Decreases p-ERK and p-JNK expression.

Cell Line:

RAW 264.7 cells

Concentration:

10 µM, 20 µM and 40 µM

Incubation Time:

24 hours

Result:

Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner.

体内研究

Animal Model: Mice Dosage: 0.5 mg/kg Administration: Oral administration; 0.5 mg/kg/day; 17 days Result: Reinforced object recognition memory.

Animal Model:

Mice

Dosage:

0.5 mg/kg

Administration:

Oral administration; 0.5 mg/kg/day; 17 days

Result:

Reinforced object recognition memory.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于刺五加Acanthopanax senticosus干燥根茎。