人参皂甙 Rb3

中文名称:

人参皂甙 Rb3

中文同义词:

人参皂荚RB2;人参皂苷RB3(标准品);人参皂甙 RB3;人参皂苷RB3对照品,;红茶浸膏粉;人参皂苷RB3(人参皂荚RB2;人参皂苷 RB3, 来源于人参;GINSENOSIDE RB3 人参皂甙 RB3

英文名称:

Ginsenoside Rb3

英文同义词:

glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl6-o-beta-d-xylopyranosyl-;Ginsenoside Rb3 (CAS#68403-26-8);Gypenoside IV;hydroxydammar-24-en-20-yl6-O-β-D-;xylopyranosyl-;β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D-;[3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-12β-hydroxy-5α-dammar-24-en-20-yl]6-O-(β-D-xylopyranosyl)-β-D-glucopyranoside;GINSENOSIDE Rb3(SH)

CAS号:

68406-26-8

分子式:

C53H90O22

分子量:

1079.27

EINECS号:

相关类别:

中药对照品;标准品;生化试剂;对照品,标准品;分析标准品;植物提取物;对照品;植提标准品;中药标准品;中药提取物;化学试剂;分析试剂标准品;原料药;生化试剂-其他化学试剂;标准品-中药标准品;标准品，对照品;原料;标准品 -中药标准品;Ginsenoside series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;三萜;分析试剂-对照品

Mol文件:

68406-26-8.mol

熔点 

193～195℃

沸点 

1117.1±65.0 °C(Predicted)

密度 

1.42±0.1 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

12.85±0.70(Predicted)

形态

neat

CAS 数据库

68406-26-8

生物活性

Ginsenoside Rb3 是从人参中提取的天然产物，在心血管疾病包括心肌的缺血/再灌注(I/R)损伤中起着重要作用。在人肾293T细胞中检测了Ginsenoside Rb3(0.1-10 μM)对肿瘤坏死因子TNF-α诱导的 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) 荧光素酶报告基因的抑制作用，IC50值为8.2 μM。在用10 ng/mL TNF-α处理后的HepG2细胞中，Ginsenoside Rb3 还以剂量依赖性的方式抑制 cyclooxygenase-2 (COX-2) 和 inducible nitric oxide synthase (iNOS) 信使mRNA的诱导诱导表达。

靶点

Target Value COX-2 () iNOS () NF-κB (human kidney 293T cell-based assay) 8.2 μM

Target

Value

COX-2 ()

iNOS ()

NF-κB (human kidney 293T cell-based assay)

8.2 μM

体外研究

Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC 50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL). Ginsenoside Rb3 (0.1-10 μM) significantly increases cell viability and inhibits lactate dehydrogenase (LDH) release in a dose-dependent manner. PC12 cell viability as determined by MTT reduction is also markedly decreased after the cell is exposed to oxygen and glucose deprivation (OGD)/OGD-Rep. But, when the cells are pretreated with Ginsenoside Rb3 (0.1, 1, and 10 μM), OGD/OGD-Rep induced cell toxicity is significantly attenuated, which is concentration-dependently attenuated by Ginsenoside Rb3 treatment. The viabilities are raised to 52.8%±5.6%, 64.6%±5.7%, and 76.4%±8.8%, respectively, compared with the control group.

体内研究

Ginsenosides Rb3 is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment and induces anti-polyposis in Apc Min/+ mice. Six-weeks-old mice are subjected to Rb3 treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Rb3 treatments.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参，绞股蓝。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:人参皂苷Rb3能改善神经功能缺损，缩小脑内梗死面积，缓解脑水肿；人参皂苷Rb3可以通过抗氧化损伤从而保护脑缺血损伤。

用途 

人参皂苷Rb3是一种天然三萜皂苷，具有多重药理作用。

安全说明 

24/25

WGK Germany 

3

RTECS号

LZ5857000

海关编码 

29389090