脱氢吴茱萸碱

中文名称:

脱氢吴茱萸碱

中文同义词:

DEHYDROEVODIAMINE 去氢吴茱萸碱;去氢吴茱萸碱 标准品;脱氢吴茱萸碱;去氢吴茱萸碱;去氢吴茱萸碱对照品

英文名称:

Dehydroevodiamine

英文同义词:

Dehydroevodiamine;14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2,3:3,4]pyrido[2,1-b]quinazoline-14-ium;5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2,3:3,4]pyrido[2,1-b]quinazolin-14-ium;8,13-Dihydro-14-methyl-5-oxoindolo[2,3:3,4]pyrido[2,1-b]quinazolinium inner salt;14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2,3:3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide;Indolo[2,3:3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt

CAS号:

67909-49-3

分子式:

C19H15N3O

分子量:

301.35

EINECS号:

200-258-5

相关类别:

植物提取物;标准品;对照品;中药对照品;分析试剂标准品;对照品-中药对照品;标准品 -中药标准品;reagent;standard substance;标准品，对照品

Mol文件:

67909-49-3.mol

熔点 

190-192℃

储存条件 

Sealed in dry,2-8°C

概述

吴茱萸始载于《神农本草经》，具有散寒止痛、降逆止呕、降压等功能。国内外研究发现，其化学成分之一的脱氢吴茱萸碱具有较强的体外抗乙酰胆碱酯酶及修复脑细胞治疗中风等作用。

生物活性

Dehydroevodiamine 是从吴茱萸 Evodiae Fructus 中分离出的喹唑啉生物碱，对豚鼠心室肌细胞具有抗心律失常作用。Dehydroevodiamine 抑制 LPS 诱导的小鼠巨噬细胞中 iNOS，COX-2，PGE2 和 NF-κB 的表达。

靶点

Target Value NF-κB () COX-2 () iNOS () PGE2 ()

Target

Value

NF-κB ()

COX-2 ()

iNOS ()

PGE2 ()

体外研究

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression. Western Blot Analysis Cell Line: RAW 264.7 macrophage cells Concentration: 10 μM, 30 μM, 50 μM Incubation Time: pretreated 2 hours Result: Reduced iNOS and COX-2 expression and increased IκB-α expression. RT-PCR Cell Line: RAW 264.7 macrophage cells Concentration: 10 μM, 30 μM, 50 μM Incubation Time: pretreated 2 hours Result: Reduced iNOS and COX-2 mRNA expression.

Cell Line:

RAW 264.7 macrophage cells

Concentration:

10 μM, 30 μM, 50 μM

Incubation Time:

pretreated 2 hours

Result:

Reduced iNOS and COX-2 expression and increased IκB-α expression.

Cell Line:

RAW 264.7 macrophage cells

Concentration:

10 μM, 30 μM, 50 μM

Incubation Time:

pretreated 2 hours

Result:

Reduced iNOS and COX-2 mRNA expression.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于疏毛吴茱萸干燥近成熟果实。

用途 

去氢吴茱萸碱具有降压、抗肿瘤的作用。