儿茶素没食子酸酯

中文名称:

儿茶素没食子酸酯

中文同义词:

儿茶素没食子酸;(-)-没食子酸儿茶素酯;(2S,3R)-2-(3,4-二羟苯基)-3,4-二氢-1(2H)-苯并-3,5,7-三醇3-(3,4,5-三羟基苯甲酸);儿茶素没食子酸酯;(-)-儿茶素没食子酸酯;(-)-儿茶素没食子酸酯, 来源于绿茶;儿茶素没食子酸酯CG;儿茶素没食子酯酸

英文名称:

(-)-CATECHIN GALLATE

英文同义词:

Catechin gallate CG (-)-Catechin gallate;(-)-Catechin 3-O-gallate);(-)-Catechin gallate ((-)-Catechin 3-gallate;(-)-Catechin gallate(CG);Anti-HCG β, C-Terminal antibody produced in rabbit;Choriogonadotropin subunit β;Chorionic gonadotrophin chain β;ANTI-CG antibody produced in mouse

CAS号:

130405-40-2

分子式:

C22H18O10

分子量:

442.37

EINECS号:

相关类别:

标准品;植物提取物;对照品-杂质对照品;合成;对照品;中药对照品;对照品-中药对照品;Catechins Tannins;Aromatics;Chiral Reagents;Inhibitors;Intermediates Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品 -中药标准品;标准品，对照品

Mol文件:

130405-40-2.mol

熔点 

248-251 °C (decomp)

沸点 

861.7±65.0 °C(Predicted)

密度 

1.80±0.1 g/cm3(Predicted)

储存条件 

2-8°C

酸度系数(pKa)

7.75±0.25(Predicted)

InChIKey

LSHVYAFMTMFKBA-CTNGQTDRSA-N

生物活性

(-)-Catechin gallate 是绿茶儿茶素中的一种微量组分。(-)-Catechin gallate 抑制 COX-1 和 COX-2 活性。

靶点

COX-1 COX-2

COX-1

COX-2

体外研究

(-)-Catechin gallate (CG) directly interacts with DNA oligomers and inhibits the activity of COX-1 and COX-2 enzymes, the gene expression of matrix metalloproteinase-9 in macrophage-differentiated HL-60 myeloid leukemia cells, the adipocyte uptake of glucose by the transporter, GLUT4, and the activities of various proteasomes, i.e., the multicatalytic proteases responsible for the degradation of most cellular proteins. The relative cytotoxicities of a 3-day exposure to (-)-Catechin gallate are determined for cancerous CAL27 and HSG cells, immortalized epithelioid S-G cells, and normal HGF-1 gingival fibroblasts. The concentration at which toxicity (P≤0.01) initially occur is 25 μM (-)-Catechin gallate for S-G cells, 50 μM (-)-Catechin gallate for CAL27 cells, 62.5 μM (-)-Catechin gallate for HSG cells and 75 μM (-)-Catechin gallate for HGF-1 fibroblasts. The calculated neutral red (NR 50 ) values for a 3-day exposure to (-)-Catechin gallate are 58 μM for S-G cells, 62 μM for CAL27 cells, 90 μM for HSG cells and 132 μM for HGF-1 fibroblasts.

化学性质 

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于绿茶。

用途 

儿茶素没食子酸酯具有抗炎，镇痛，镇静的作用。

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36

WGK Germany 

3

海关编码 

29329990