葫芦巴碱

中文名称:

葫芦巴碱

中文同义词:

葫蘆巴鹼;菸鹼酸N-甲內鹽;N-甲菸鹼酸內鹽;烟酸甜菜碱;葫芦巴碱;1-甲基吡啶鎓-3-甲酸内盐;1-甲基吡啶-3-甲酸内盐;葫芦巴碱 (1-甲基吡啶鎓-3-甲酸内盐

英文名称:

Trigonelline

英文同义词:

betainnicotinate;Caffearine;Coffearin;Coffearine;Gynesine;n’-methylnicotinicacid;Nicotinic acid N-methylbetaine;nicotinicacidn-methylbetaine

CAS号:

535-83-1

分子式:

C7H7NO2

分子量:

137.14

EINECS号:

208-620-5

相关类别:

小分子抑制剂;对照品;小分子抑制剂，天然产物;分析试剂标准品;分析对照品;标准提取物;中药对照品;标准品;对照品,标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;标准品-对照品;标准品-中药标准品;其他原料;标准品 -中药标准品;标准品，对照品

Mol文件:

535-83-1.mol

熔点 

260°C (dec.)

沸点 

251.96°C (rough estimate)

密度 

1.2528 (rough estimate)

折射率 

1.5030 (estimate)

生物活性

Trigonelline (Trigenolline) 是一种植物生物碱，是咖啡和葫芦巴的主要成分，具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路，例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。

靶点

Target Value PLCγ1 () PI3K () Akt () microtubule ()

Target

Value

PLCγ1 ()

PI3K ()

Akt ()

microtubule ()

体外研究

It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .

体内研究

Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.

化学性质 

白色结晶性粉末，溶于甲醇和水，来源于葫芦巴、使君子，大豆。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:为胡芦巴中的主要成分，具有抗肿瘤作用。

用途 

用作营养型添加剂，医药中间体

安全说明 

24/25

海关编码 

29339900