三角叶薯蓣皂苷

中文名称:

三角叶薯蓣皂苷

中文同义词:

三角叶薯蓣皂甙;三角叶薯蓣皂苷;三角叶薯蓣皂苷标准品;三角叶薯蓣皂苷对照品

英文名称:

deltonin

英文同义词:

deltonin;3-O-beta-D-Glucopyranosyl(1-4)-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside-diosgenin;Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin;β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-

CAS号:

55659-75-1

分子式:

C45H72O17

分子量:

885.04

EINECS号:

相关类别:

标准品;分析试剂标准品;对照品;标准品，对照品

Mol文件:

55659-75-1.mol

熔点 

298-300 °C (decomp)

密度 

1.42±0.1 g/cm3(Predicted)

酸度系数(pKa)

12?+-.0.70(Predicted)

概述

黄姜，学名盾叶薯蓣(DioscoreazingiberensisC.H.Wright)，系薯蓣科薯蓣属植物，为我国特有的野生植物资源。三角叶薯蓣皂苷(Deltonin)是盾叶薯蓣所含有的多种皂苷的一种。三角叶薯蓣皂苷具有在对抗心血管疾病方面的多种药理活性，如：保护血管内皮细胞，降血脂，预防和治疗血栓，改善冠状动脉供血以及预防和治疗心肌梗死。

生物活性

Deltonin 是从盾叶薯蓣中得到的甾体皂苷，能够抑制 ERK1/2 和 AKT 的活化，具有抗肿瘤的活性。

靶点

ERK1 ERK2 Akt Human Endogenous Metabolite

ERK1

ERK2

体外研究

Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC 50 s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA‑MB‑231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA‑MB‑231 cells.

体内研究

Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.