萝卜硫苷

中文名称:

萝卜硫苷

中文同义词:

萝卜硫素GLUCOSIN醇ATE;萝卜硫苷(西兰花子水提取物);萝卜硫苷;萝硫甙;萝卜硫甙;硫代葡萄糖苷钾盐;西兰花提取物:萝卜硫甘;西兰花种子提取物:萝卜硫甘

英文名称:

GLUCORAPHANIN

英文同义词:

4-METHYLSULFINYLBUTYLGLUCOSINOLATE;1-Thio-β-D-glucopyranose 1-[N-(hydroxysulfonyloxy)-5-(methylsulfinyl)pentanimidate];1-Thio-β-D-glucopyranose 1-[N-(hydroxysulfonyloxy)-5-methylsulfinylpentanimidate];N-(Hydroxysulfonyloxy)-5-(methylsulfinyl)pentanimidothioic acid β-D-glucopyranosyl ester;GLUCORAPHANIN POTASSIUM SALT(RG);GLUCORAPHANIN;GLUCORAPHANIN POTASSIUM SALT(P);GLUCORAPHANIN POTASSIUM SALT(SH)

CAS号:

21414-41-5

分子式:

C12H23NO10S3

分子量:

437.51

EINECS号:

相关类别:

标准品;植物提取物;提取物;对照品;对照品;标准品-对照品;生物碱;标准品 -中药标准品;标准品，对照品;产品

Mol文件:

21414-41-5.mol

密度 

1.78±0.1 g/cm3 (20 ºC 760 Torr)

储存条件 

Sealed in dry,2-8°C

形态

White solid.

酸度系数(pKa)

-2.93±0.18(Predicted)

用途

萝卜硫苷 是西兰花提取物的一个有效成分，也是萝卜硫素的前体药物，萝卜硫苷可以在体内转化为萝卜硫素，从而发挥抗癌抗氧化的功效。

生物活性

Glucoraphanin 是存在于十字花科蔬菜中的硫代葡萄糖苷，是 Nrf2 诱导剂 sulforaphane 的前体，后者具有抗氧化、抗炎、抗癌的作用。

体内研究

Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2 −/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2 −/− mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice.

化学性质 

类白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于莱菔子。

用途 

抗癌抗氧化。

用途 

用于含量测定/鉴定/药理实验等。