硬脂醇甘草亭酸酯

中文名称:

硬脂醇甘草亭酸酯

中文同义词:

甘草次酸十八酯;硬脂基甘草亭酸酯;硬脂酰基甘草酸;硬脂醇甘草亭酸酯;硬脂醇甘草亭酸脂;甘草酸硬脂酯;甘草次酸十八酯标准品;甘草亭酸酯

英文名称:

Stearyl glycyrrhetinate

英文同义词:

Stearyl alcohol licorice ester;octadecyl (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate;Stearyl glycyrrhizinate;Stearyl Glycyrrhetinate natural licorice extra;Octadecyl3-hydroxy-11-oxoolean-12-en-29-oate;Stearylglycyrrhetate;Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, octadecyl ester, (3.beta.,20.beta.)-;RYL GLYCYRRHETINATE

CAS号:

13832-70-7

分子式:

C48H82O4

分子量:

723.16

EINECS号:

419-580-5

相关类别:

对照品;标准品;甘草;中药对照品;植物提取物;医药原料;植提;香精香料;化妆品日化原料;日化原料;对照品-中药对照品;标准品 -中药标准品;化妆品原料

Mol文件:

13832-70-7.mol

熔点 

70-77 °C

沸点 

732.5±60.0 °C(Predicted)

密度 

1.01±0.1 g/cm3(Predicted)

酸度系数(pKa)

15.11±0.70(Predicted)

BRN 

7612541

InChIKey

WNIFXKPDILJURQ-JKPOUOEOSA-N

生物活性

Stearyl glycyrrhetinate 是甘草提取物中的主要成分之一，对金黄色葡萄球菌菌株的 MIC 大于 256 mg/L。Stearyl glycyrrhetinate 具有抗菌 (antibacterial) 作用。

体外研究

Glycyrrhetinic acid (GRA) and disodium succinoyl glycyrrhetinate (GR-SU) shows strong antibacterial activities compared to the other three agents tested. At a higher concentration (above 2x MIC), GRA and GR-SU shows bactericidal activity, whereas at a concentration of 1x MIC, they showed a bacteriostatic effect.

化学性质 

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甘草Glycyrrhiza inflata。

用途 

甘草次酸十八酯具有抗过敏、抗菌消炎、治疗溃疡等作用。

WGK Germany 

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