大戟二烯醇

中文名称:

大戟二烯醇

中文同义词:

大戟二烯醇;大戟二烯醇对照品

英文名称:

euphol

英文同义词:

Lanosta-8,24-dien-3-ol,(3b,13a,14b,17a)-;euphol;5.α.-Eupha-8,24-dien-3.β.-ol;Euphol, Euphadienol;alpha-Eupho;(13α,14β,17α)-5α-Lanosta-8,24-dien-3β-ol;Euphadienol;Lanosta-8,24-dien-3-ol, (3β,13α,14β,17α)-

CAS号:

514-47-6

分子式:

C30H50O

分子量:

426.72

EINECS号:

相关类别:

中药对照品;标准品;植物提取物;对照品;对照品-中药对照品;标准品 -中药标准品;三萜;标准品，对照品

Mol文件:

514-47-6.mol

熔点 

116-117℃

沸点 

498.9±44.0 °C(Predicted)

密度 

0.98±0.1 g/cm3 (20 ºC 760 Torr)

酸度系数(pKa)

15.16±0.70(Predicted)

生物活性

Euphol 是一种四环三萜醇，是从 Euphorbia tirucalli 的汁液中分离出来的，具有抗炎和免疫调节作用，具有口服活性。 Euphol 通过一种可逆机制抑制单酰基甘油脂肪酶 (MGL) 的活性，IC50=315 nM。 外周 MGL 抑制可调节内源性大麻素系统从而阻止炎症性疼痛的发展。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC 50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins. Cell Proliferation Assay Cell Line: T47D cells Concentration: 0.01, 0.03, 0.1 and 0.3 mM Incubation Time: 24, 48 and 72 hours Result: Decreased the percentage of viable cells. Western Blot Analysis Cell Line: T47D cells Concentration: 0.03 mM Incubation Time: 48 and 72 hours Result: Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D.

Cell Line:

T47D cells

Concentration:

0.01, 0.03, 0.1 and 0.3 mM

Incubation Time:

24, 48 and 72 hours

Result:

Decreased the percentage of viable cells.

Cell Line:

T47D cells

Concentration:

0.03 mM

Incubation Time:

48 and 72 hours

Result:

Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D.

化学性质 

白色粉末，易溶于正己烷、三氯甲烷、甲醇，来源于甘遂，京大戟。

用途 

大戟二烯醇具有抗高血压的作用。