灵芝酸A

中文名称:

灵芝酸A

中文同义词:

灵芝酸A;灵芝酸 A(96%);灵芝酸 A, 来源于灵芝;灵芝酸A(95%);灵芝酸A(标准品);GANODERENIC ACID A 灵芝酸A;灵芝酸 A?, >98%;JAK-STAT3信号通路抑制剂(GANODERIC ACID A)

英文名称:

GANODERIC ACID A

英文同义词:

(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid;Aids070759;Aids-070759;Lanost-8-en-26-oic acid, 7,15-dihydroxy-3,11,23-trioxo-, (7.beta.,15.alpha.,25R)-;(7beta,15alpha,25R)-7,15-Dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid;GANODERIC ACID A(P);GANODERIC ACID A;(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oicaci

CAS号:

81907-62-2

分子式:

C30H44O7

分子量:

516.67

EINECS号:

相关类别:

标准品-对照品;细胞生物学试剂;分析试剂标准品;对照品;中药对照品;植提标准品;植物提取物;对照品，标准品，生物试剂，植物单体;标准品;对照品、标准品、植物单体;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;三萜;标准品 -中药标准品;标准品，对照品

Mol文件:

81907-62-2.mol

熔点 

118～123℃

沸点 

690.1±55.0 °C(Predicted)

密度 

1.22

储存条件 

Sealed in dry,Store in freezer, under -20°C

酸度系数(pKa)

4.78±0.23(Predicted)

生物活性

Ganoderic acid A 能够抑制 JAK-STAT3 信号通路，也能抑制细胞增殖，存活率和 ROS。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma. Ganoderic acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression. Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner. Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells.

体内研究

Ganoderic acid A treatment significantly prolonged survival of EL4 challenged mice and decreased tumor metastasis to the liver.

化学性质 

白色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于灵芝，赤芝。

用途 

灵芝酸A具有降血脂、降血压、护肝、调节肝功能的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:抑制细胞组织胺的释放，增强消化系统各种器官的机能，具有降血脂、降血压、护肝、调节肝功能等作用。

安全说明 

24/25

海关编码 

29189900