人参皂苷 RH3

中文名称:

人参皂苷 RH3

中文同义词:

人参皂苷 S-RH3;人参皂苷RH3(标准品);人参皂苷 RH3;人参皂苷RH3对照品,;20(S)-人参皂苷RH3, 来源于人参根茎

英文名称:

ginsenoside Rh3

英文同义词:

[(20Z)-12β-Hydroxy-5α-dammara-20(22),24-dien-3β-yl]β-D-glucopyranoside;ginsenoside Rh3;b-D-Glucopyranoside, (3b,12b,20Z)-12-hydroxydammara-20(22),24-dien-3-yl;20(S)-Ginsenoside Rh3, 98%, from panax ginseng C. A. Mey.;β-D-Glucopyranoside, (3β,12β,20Z)-12-hydroxydammara-20(22),24-dien-3-yl;ginsenoside Rh3 USP/EP/BP;(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(8R,10R,12S,13R,14S,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2Z)-6-methylhepta-2,5-dien-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-3,4,5-triol

CAS号:

105558-26-7

分子式:

C36H60O7

分子量:

604.86

EINECS号:

相关类别:

中药对照品;标准品;生化试剂;分析试剂标准品;对照品;植提标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Triterpenoids;标准品-中药标准品;标准品 -中药标准品;分析试剂-对照品;标准品-对照品

Mol文件:

105558-26-7.mol

沸点 

695.0±55.0 °C(Predicted)

密度 

1.17±0.1 g/cm3(Predicted)

酸度系数(pKa)

12.91±0.70(Predicted)

简介

人参皂苷Rh3是Rg5通过生物代谢转化而来的一种分子量更小的人参皂苷，它的功效比Rg5更强。

生物活性

Ginsenoside Rh3 是 Ginsenoside Rg5 的一种细菌代谢产物。在人视网膜细胞中 Ginsenoside Rh3 可诱导 Nrf2 激活。

靶点

Nrf2

体外研究

Ginsenoside Rh3 inhibits UV-induced oxidative damages in retinal cells via activating nuclear-factor-E2-related factor 2 (Nrf2) signaling. Ginsenoside Rh3 treatment in retinal cells induces Nrf2 activation. The potential activity of Ginsenoside Rh3 is tested on Nrf2 signaling in the retinal pigment epithelium cells (RPEs). The qRT-PCR assay results demonstrate that treatment with Ginsenoside Rh3 dose-dependently increases mRNA transcription and expression of key Nrf2-regulated genes, including HO1 , NQO1 and GCLC . Consequently, protein expressions of these Nrf2-dependent genes (HO1, NQO1 and GCLC) are also significantly increased in Ginsenoside Rh3 (3-10 μM)-treated RPEs. Notably, although Nrf2 mRNA level is unchanged after Ginsenoside Rh3 treatment, its protein level is significantly increased by Rh3. EZ-Cytox assay is used to assess the effect of ginsenoside-Rh3 on SP 1-keratinocytes viability. Ginsenoside Rh3 (0.01, 0.1, 1 and 10 μM) shows no cytotoxic effect at all concentrations.

体内研究

The potential effect of Ginsenoside Rh3 is examined on mouse retina, using the light-induced retinal damage model. Ginsenoside Rh3 intravitreal injection (5 mg/kg body weight, 30 min pre-treatment) significantly attenuates light-induced decrease of both a- and b-wave amplitude. The electroretinography (ERG)s a-wave decreases to 46.03±1.62% % of control level after light exposure, which is back to 71.84±7.51% with Ginsenoside Rh3 administration. The b-wave is 40.19±3.34% of control level by light exposure, and Rh3 intravitreal injection brings back to 80.01±2.37% of control level.

化学性质 

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参根茎。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:具有抗炎作用，可显著抑制LPS诱导活化的小神经胶质细胞表达iNOs和前炎症细胞因子。

用途 

人参皂苷Rh3是人参皂苷Rg5的代谢产物，具有抗炎等活性。