人参皂甙 Rh1

中文名称:

人参皂甙 Rh1

中文同义词:

人参皂苷-RH1;人参皂苷 S-RH1;人参皂苷RH1(标准品);人参皂苷RH1(S)/20(S)-人参皂苷RH1;(R型)人参皂苷RH1;人参皂荚RH1;人参皂苷RH1, 来源于人参;(S型)人参皂苷RH1

英文名称:

Ginsenoside Rh1

英文同义词:

sanchinoside rh1;(3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl?beta-d-glucopyranoside;Ginsenoside Rh1 (Prosapogenin A2;GINSENOSIDE RH1;(20S)-6α-(β-D-Glucopyranosyloxy)-3β,12β,20-trihydroxydammara-24-ene;(20S)-6α-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β,20-triol;3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl β-D-glucopyranoside;6α-(β-D-Glucopyranosyloxy)-dammara-24-ene-3β,12β,20-triol

CAS号:

63223-86-9

分子式:

C36H62O9

分子量:

638.88

EINECS号:

相关类别:

中药对照品;标准品;生化试剂;对照品,标准品;分析标准品;植物提取物;小分子抑制剂，天然产物;Ginsenoside series;chemical reagent;pharmaceutical intermediate;对照品;植提标准品;小分子抑制剂;Inhibitors;中药标准品;化学试剂;生化试剂-其他化学试剂;标准品-中药标准品;标准品 -中药标准品;三萜;分析试剂-对照品;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

63223-86-9.mol

沸点 

755.1±60.0 °C(Predicted)

密度 

1.23

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

12.91±0.70(Predicted)

理化性质

人参皂苷Rh1来源为五加科植物人参Panax ginseng C. A. Mey.的干燥根,是一种白色粉末状物质，溶解性:易溶于水、甲醇、乙醇，不溶于乙/醚、苯。

生物活性

20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1)是从红参中提取的主要生物活性化合物之一，在世界范围内，红参已越来越多地用于增强认知和身体健康。它具有抗发炎、抗氧化、免疫调节作用和对神经系统有积极作用的有效特性。20(S)-Ginsenoside Rh1 可抑制 PPAR-γ、TNF-α、IL-6 和 IL-1β 的表达。

靶点

PPAR-γ TNF-α IL-6 IL-1β Human Endogenous Metabolite

PPAR-γ

TNF-α

体外研究

The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected.

体内研究

When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone.

化学性质 

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:具有滋补强壮，抗肿瘤作用。

用途 

(20S)-人参皂苷Rh1是人参中的主要成分之一，具有抗炎作用。