人参皂苷 Rg2

中文名称:

人参皂苷 Rg2

中文同义词:

人参皂苷RG2(20(S)-人参皂苷RG2,人参皂甙RG2);S-人参皂苷RG2,人参皂甙RG2;GINSENOSIDE RG2 人参皂苷RG2;人参皂荚RG2;人参皂苷RG2(标准品);人参皂苷RG2/20(S)-人参皂苷RG2;(S型)人参皂苷RG2;人参皂苷RG2(S)

英文名称:

Ginsenoside Rg2

英文同义词:

anaxatriol;beta-d-glucopyranoside,(3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en;mannopyranosyl)-;trihydroxydammar-24-en-6-yl2-O-(6-deoxy-α-L-;β-D-Glucopyranoside,(3β,6α,12β)-3,12,20-;Ginsenoside 20(s)-Rg2;(20S)-Ginsenoside Rg2;[3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

CAS号:

52286-74-5

分子式:

C42H72O13

分子量:

785.03

EINECS号:

相关类别:

分析标准品;植物提取物;中药对照品;标准品;生化试剂;标准品-对照品;化学试剂;pharmaceutical intermediate;phytochemical;对照品;植提标准品;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物;中药标准品;生化试剂-其他化学试剂;标准品-中药标准品;标准品，对照品;标准品 -中药标准品;三萜;分析试剂-对照品;Saponins;Ginsenoside series;chemical reagent;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

52286-74-5.mol

熔点 

187～189℃

沸点 

881.0±65.0 °C(Predicted)

密度 

1.30±0.1 g/cm3(Predicted)

储存条件 

2-8°C

酸度系数(pKa)

12.85±0.70(Predicted)

InChIKey

AGBCLJAHARWNLA-DJZXLMSJSA-N

简介

人参皂苷 Rg2 是人参的主要活性成分之一。人参皂苷 Rg2 是一种 NF-κB 抑制剂。 人参皂苷 Rg2还降低 Aβ1-42 积聚。

作用功效

人参皂苷Rg2对急性心源性休克有保护作用，具有抗休克、抗心衰、抗凝血、抗血栓作用。主要表现在强壮心肌，增强心肌收缩力，减慢心率，扩张血管，增加心输出量和提高冠脉流量，能快速改善心肌缺血和缺氧，具有明显的增强心功能作用。

生物活性

Ginsenoside Rg2 是人参的主要活性成分之一。Ginsenoside Rg2 是一种 NF-κB 抑制剂。 Ginsenoside Rg2 还降低 Aβ1-42 积聚。

靶点

NF-κB Aβ 1-42

NF-κB

Aβ 1-42

体外研究

Ginsenoside Rg2 prevents the decrease of IκB expression stimulated with lipopolysaccharide (LPS). IκB dissociation from RelA-p50 complex is crucial for NF-κB activity. Ginsenoside Rg2, protopanaxatriol, inhibits vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression stimulated with LPS from human umbilical vein endothelial cell (HUVEC). The inhibition of VCAM-1 and ICAM-1 expression by Ginsenoside Rg2 is in a concentration-dependent manner, significantly. Treatment of endothelial cells with LPS (1µg/mL) decreases IκBα expression. By 1 hr after LPS treatment, significant decrease of IκBα is attained. To determine whether LPS-stimulated IκBα expression is affected by Ginsenoside Rg2, endothelial cells are treated for 1 hr with Ginsenoside Rg2 (1~50 µM) prior to LPS (1 µg/mL) stimulation for 1 hr. Ginsenoside Rg2 reverses the decrease of LPS-induced IκBα expression in a concentration-dependent manner, significantly. The adhesion of THP-1 cells to endothelial cells is measured using quantitative monolayer adhesion assay. The adhesion of THP-1 cells onto endothelial cells are increased to five folds by LPS (1 µg/mL) stimulation for 8 hrs. Ginsenoside Rg2 (1~50 µM) inhibits the adhesion of THP-1 cells to endothelial cells stimulated with LPS, in a concentration-dependent manner.

体内研究

G-Rg1 and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimers disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with G-Rg1 and Ginsenoside Rg2 (G-Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with G-Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. G-Rg1 and Ginsenoside Rg2 reduce Aβ 1-42 accumulation in APP/PS1 mice. In the G-Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参、西洋参。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:够增强心肌的收缩力,增加心输出量,同时增强缺血心肌血流量。

用途 

(20S)-人参皂苷Rg2是富含于人参中的甾醇皂苷，具有很高的生物活性。

危险品标志 

Xn

危险类别码 

22

安全说明 

24/25

WGK Germany 

3

RTECS号

LZ6430000

海关编码 

29389090