人参皂甙 Rc

中文名称:

人参皂甙 Rc

中文同义词:

人参皂苷RC(人参皂甙RC);GINSENOSIDE RC 人参皂苷RC;人参皂苷RC;人参皂甙RC;人参皂苷 RC, 来源于人参;人叁皂甙RC;人参皂荚RB1;人参皂荚RC

英文名称:

Ginsenoside Rc

英文同义词:

20-[(6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside;GINSENOSIDE FROM GINSENG ROOT (PANAX*QUI NQUEFOLIUM;20-[(6-O-alpha-L-Arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12b-hydroxydammar-24-en-3b-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside;GINSENOSIDE RC WITH HPLC;arabinofuranosyl-β-D-glucopyranosyl)oxy]-12-;glucopyranosyl-;hydroxydammar-24-en-3-yl2-O-β-D-;ginsenoside-rc from panax quinquefolium (american ginseng)root

CAS号:

11021-14-0

分子式:

C53H90O22

分子量:

1079.27

EINECS号:

234-253-5

相关类别:

标准品-中药标准品;植提;小分子抑制剂，天然产物;有机硼化合物;小分子抑制剂;中药对照品;标准品;对照品,标准品;分析标准品;植物提取物;对照品;植提标准品;中药标准品;化学试剂;分析试剂标准品;生化试剂-其他化学试剂;标准品，对照品;三萜;标准品 -中药标准品;分析试剂-对照品;标准品-对照品;Saponins;Biochemicals Found in Plants;Isoprenoid/terpenoid;Nutrition Research;Ginsenoside series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors

Mol文件:

11021-14-0.mol

熔点 

199～201℃

沸点 

1128.3±65.0 °C(Predicted)

密度 

1.42±0.1 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

12.85±0.70(Predicted)

CAS 数据库

11021-14-0(CAS DataBase Reference)

生物活性

Ginsenoside Rc 是主要的人参皂甙之一，Ginsenoside Rc 增强 GABA 受体 A (GABAA) 介导的离子通道 (IGABA)。 Ginsenoside Rc 还抑制 TNF-α 和 IL-1β 表达。

靶点

TNF-α IL-1β

TNF-α

IL-1β

体外研究

Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor A (GABA A )-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参根茎。

用途 

应用于医药保健行业，可以配制成抗疲劳、抗衰老以及健脑的保健食品；

用途 

人参皂苷Rc属于甾体和三萜类皂苷，在参属植物中独有，有抑制或阻止肿瘤的生长特性。

危险品标志 

Xn

危险类别码 

20/21/22

安全说明 

26-36

WGK Germany 

3

RTECS号

LY9536300

海关编码 

29389090