6-甲氧基藤黄菌素

中文名称:

6-甲氧基藤黄菌素

中文同义词:

泽兰黄酮;6-甲氧基藤黄菌素;泽兰叶黄素;6-甲氧基木犀草素, 来源于泽兰;泽兰黄酮(6-甲氧基藤黄菌素

英文名称:

6-METHOXYLUTEOLIN

英文同义词:

EUPAFOLIN;NSC 122416;Eupafolin(Nepetin,NSC 122416);Eurafolin;Eupafloin 6-Methoxyluteolin;6-METHOXYLUTEOLIN;NEPETIN;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one

CAS号:

520-11-6

分子式:

C16H12O7

分子量:

316.26

EINECS号:

相关类别:

标准品;对照品;中药对照品;植物提取物;黄酮;标准品 -中药标准品;标准品，对照品;Tetra-substituted Flavones;化工原料

Mol文件:

520-11-6.mol

熔点 

267°C

沸点 

659.1±55.0 °C(Predicted)

密度 

1.605

闪点 

90℃

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

6.48±0.40(Predicted)

生物活性

Nepetin (6-Methoxyluteolin) 是从 Eupatorium ballotaefolium HBK 分离的天然类黄酮，具有有效的抗炎活性。Nepetin 在 ARPE-19 细胞中抑制 IL-6，IL-8 和 MCP-1 分泌，IC50 值分别为 4.43 μM、3.42 μM 和 4.17 μM。

体外研究

Pretreatment with Nepetin dose-dependently inhibited IL-6, IL-8 and MCP-1 secretion with IC 50 values of 4.43, 3.42 and 4.17 μM, respectively. Nepetin (2.5-10 μM; 25 hours; ARPE-19 cells) treatment suppresses IL-1β-induced cytokine (IL-6, IL-8 and MCP-1) expression at mRNA level in ARPE-19 cells. Nepetin (2.5-10 μM; 1.5 hours; ARPE-19 cells) treatment dose-dependently inhibits phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Nepetin decreases the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells. RT-PCR Cell Line: ARPE-19 cells Concentration: 2.5 μM, 5 μM, 10 μM Incubation Time: 25 hours Result: Suppressed the mRNA expression of IL-6, IL-8 and MCP-1 in ARPE-19 cells. Western Blot Analysis Cell Line: ARPE-19 cells Concentration: 2.5 μM, 5 μM, 10 μM Incubation Time: 1.5 hours Result: Dose-dependently inhibited phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Decreased the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells.

Cell Line:

ARPE-19 cells

Concentration:

2.5 μM, 5 μM, 10 μM

Incubation Time:

25 hours

Result:

Suppressed the mRNA expression of IL-6, IL-8 and MCP-1 in ARPE-19 cells.

Cell Line:

ARPE-19 cells

Concentration:

2.5 μM, 5 μM, 10 μM

Incubation Time:

1.5 hours

Result:

Dose-dependently inhibited phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Decreased the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells.

化学性质 

黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于艾蒿叶， 银蒿地上部分 线形旱地菊地上部分。

用途 

抗肿瘤、杀虫、抗SARS病毒，抗菌。