二氢欧山芹醇当归酸酯

中文名称:

二氢欧山芹醇当归酸酯

中文同义词:

二氢欧山芹醇当归酸酯;二氢欧山芹当归酸酯;二氢欧山芹醇当归酸酯(标准品);氢欧山芹醇当归酸酯;二氢欧山芹醇当归酸脂;二氢欧山芹醇当归酸酯, 来源于独活;COLUMBIANADIN 二氢欧山芹醇当归酸酯;二氢欧山芹醇当归酸酯(分析标准品)

英文名称:

Columbianadin

英文同义词:

(S)-8-[1-[(Z)-2-Methyl-2-butenoyloxy]-1-methylethyl]-8,9-dihydro-2H-furo[2,3-h]-1-benzopyran-2-one;Columbianadin;ColuMbianin;ZosiMin;Columbianetin angelate;Columbianadin, 98%, from Angelica pubescens Maxim.f. biserrata Shan et Yuan;Columbianadin 5058-13-9;Columbianadin Columbianadin

CAS号:

5058-13-9

分子式:

C19H20O5

分子量:

328.36

EINECS号:

相关类别:

标准品-对照品;标准品;对照品,标准品;植物提取物;中药对照品;对照品;植提标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;木脂素;标准品 -中药标准品;标准品，对照品

Mol文件:

5058-13-9.mol

熔点 

117.0 to 121.0 °C

沸点 

482.3±45.0 °C(Predicted)

密度 

1.232±0.06 g/cm3(Predicted)

生物活性

Columbianadin 是来自 Angelica decursiva (Umbelliferae) 中的天然香豆素，已知具有各种生物活性，包括抗炎和抗癌作用。

靶点

Apoptosis

体外研究

Columbianadin (CBN) effectively suppresses the growth of colon cancer cells. Low concentration (up to 25 μM) of Columbianadin induces apoptosis, and high concentration (50 μM) of Columbianadin induces necroptosis. The induction of apoptosis by Columbianadin is correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, Bim and Bid, and the induction of necroptosis is related with RIP-3, and caspase-8. In addition, Columbianadin induces the accumulation of ROS and imbalance in the intracellular antioxidant enzymes such as SOD-1, SOD-2, catalase and GPx-1. Columbianadin shows the most effective growth inhibitory activity against human colorectal cancer cells. Accordingly, further study is performed using HCT116 cells to give the detailed growth-inhibitory mechanism of action mediated by Columbianadin. The cells treated with various concentrations of Columbianadin (0-100 μM) exhibit a dose- and time-dependent growth inhibition with an IC 50 value of 47.2 and 32.4 μM after 48 and 72 h incubation, respectively. Treatment of various concentrations (12.5, 25, and 50 μM) of Columbianadin for 48 h in HCT116 cells decreases the number of cells and increases the floating cells. Apparent morphological changes with round-shape and dying cells are also observed at 25 and 50 μM Columbianadin -treated cells.

体内研究

The analysis method is successfully applied to a tissue distribution study of Columbianadin (CBN) and Columbianetin (CBT) after intravenous administration of Columbianadin to rats. The results of this study indicated that Columbianadin can be detected in all of the selected tissues after i.v. administration. Columbianadin is distributed to rat tissues rapidly and can be metabolized to CBT in most detected tissues. Of the detected tissues, heart had the highest uptake of Columbianadin, which suggests that heart might be one of the main target tissues of Columbianadin .

化学性质 

白色针状结晶，易溶于甲醇、乙酸乙酯、三氯甲烷、丙酮、乙醚，来源于独活，蛇床子。

用途 

二氢欧山芹醇当归酸酯具有抗关节炎，镇痛，镇静的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:二氢山芹当归酸酯具有抗血小板聚集、抗炎、镇痛等作用。

安全说明 

24/25

海关编码 

29329990