人参皂苷RG6

中文名称:

人参皂苷RG6

中文同义词:

人参皂苷RG6;人参皂苷RG6对照品,;人参皂苷, 来源于人参;人参皂甙 RB6

英文名称:

Ginsenoside Rg6

英文同义词:

Ginsenoside Rg6;daMMar-20(21),24-diene-3β,6α,12β-trihydroxy-6-O-α-L-rhaMnopyranosyl(-1→2)-β-D-glucopyranoside;Ginsenoside Rg6, 98%, from Panax ginseng C. A. Mey.;(3beta,6alpha,12beta)-3,12-Dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside;b-D-Glucopyranoside, (3b,6a,12b)-3,12-dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-;β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-;Ginsenoside Rg6 USP/EP/BP

CAS号:

147419-93-0

分子式:

C42H70O12

分子量:

767

EINECS号:

相关类别:

对照品;中药对照品;植物提取物;分析试剂标准品;皂苷;标准品;对照品-中药对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Triterpenoids;标准品 -中药标准品;标准品-对照品;标准品，对照品

Mol文件:

147419-93-0.mol

沸点 

850.6±65.0 °C(Predicted)

密度 

1.27±0.1 g/cm3(Predicted)

储存条件 

2-8°C

酸度系数(pKa)

12.85±0.70(Predicted)

生物活性

Ginsenoside Rg6 是从三七中分离得到的成分。在 HepG2 细胞中 Ginsenoside Rg6 抑制 TNF-α 诱导的 NF-κB 转录活性， IC50 为 29.34±2.22 μM。Ginsenoside Rg6 还具有细胞凋亡诱导作用。

靶点

NF-κB 25.12 μM (IC 50 , in SK-Hep1 cell) NF-κB 29.34 μM (IC 50 , in HepG2 cell) Apoptosis

NF-κB 25.12 μM (IC 50 , in SK-Hep1 cell)

NF-κB 29.34 μM (IC 50 , in HepG2 cell)

体外研究

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC 50 of 25.12±1.04 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Ginsenoside Rg6 exhibits obvious anti-proliferative and apoptosis-inducing effects when it is applied to JK cells in vitro. Ginsenoside Rg6 blocks S arrest in the cell cycle. CCK-8 method shows that after Ginsenoside Rg6 is used, several groups with different concentrations obviously inhibits JK cell proliferation in human lymphocytoma, with evident dose dependency. Based on IC 50 , the median inhibitory concentration of Ginsenoside Rg6 is 83.08 μM.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参根茎。

用途 

人参皂苷Rg6是三七中提取的天然化合物，凋亡诱导剂。