丹酚酸 A

中文名称:

丹酚酸 A

中文同义词:

SALVIANOLIC ACID A 丹酚酸A;丹酚酸A(丹参酚酸A);丹参酚酸A, 来源于丹参根茎;丹参酚酸A;丹酚酸A(标准品);(2R)-3-(3,4-二羟基苯基)-2-[(E)-3-[2-[(E)-2-(3,4-二羟基苯基)乙烯基]-3,4-二羟基苯基]丙-2-烯酰]氧丙酸;丹酚酸 A;丹酚酸A对照品,

英文名称:

Salvianolic acid

英文同义词:

(2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid;SALVIANOLIC ACID A 98.0% BY HPLC;Danphenolic acid A;(R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)o;Salvianolic acid A, froM Salvia Miltiorrhiza;(R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)oxy)propanoic acid;(αR)-α-[[(2E)-3-[2-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid;Dan phenolic acid A hydrate

CAS号:

96574-01-5

分子式:

C26H22O10

分子量:

494.45

EINECS号:

相关类别:

中药对照品;标准品;对照品,标准品;分析标准品;植提标准品;植物提取物;对照品;Aromatics;Chiral Reagents;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;食品和饮料标准品;分析试剂标准品;标准品-对照品;标准品，对照品;标准品-中药标准品;标准品 -中药标准品;化工原料;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

96574-01-5.mol

熔点 

164-167°C

沸点 

858.7±65.0 °C(Predicted)

密度 

1.580±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

H2O: ≥19mg/mL

酸度系数(pKa)

2.78±0.10(Predicted)

形态

powder

颜色

yellow

BRN 

2660108

InChIKey

YMGFTDKNIWPMGF-UCPJVGPRSA-N

生物活性

Salvianolic acid A 可通过抑制基质金属钛酶 9 (MMP-9) 和抗炎作用来保护血脑屏障。

靶点

MMP-9

MMP-9

体内研究

A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain.

化学性质 

黄色针状结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于丹参根茎。

用途 

丹酚酸A适用于心绞痛及急性心肌梗塞，脑血栓形成的后遗症。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:抗凝血作用和显著的抗血小板聚集作用，抗分泌和抗溃疡作用等。

安全说明 

24/25

WGK Germany 

3

海关编码 

29189900