杯苋甾酮

中文名称:

杯苋甾酮

中文同义词:

杯觅甾酮;杯苋甾酮(标准品);杯苋甾酮;杯苋甾酮(杯觅甾酮);CYASTERONE 杯苋甾酮;杯苋甾酮, 来源于川牛膝

英文名称:

Cyasterone

英文同义词:

CYASTERONE;(3S,4S,5R)-4-[(2R,3R)-2,3-Dihydroxy-3-[(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-6-oxo-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl]-3,5-dimethyloxolan-2-one;(22R,24S,25S,28R)-2β,3β,14,20,22,28-Hexahydroxy-6-oxo(26-13C)-5β-stigmasta-7-ene-26-oic acid γ-lactone;7,(5BETA)-CHOLESTEN-26-CARBOXYLIC ACID-24BETA-(1-HYDROXYETHYL)-2BETA, 3BETA, 14ALPHA,20BETA, 22R-PENTOL-6-ONE GAMMA-LACTONE;Cyasterone, 98%, from Cyathula officinalis K.C. Kuan;(22r,24s,25s,28r)-gamma-lacton;2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-5-beta-stigmast-7-en-26-oicaci;cyasteron

CAS号:

17086-76-9

分子式:

C29H44O8

分子量:

520.65

EINECS号:

相关类别:

可定制;对照品;植提标准品;标准品-中药标准品;标准品-对照品;中药对照品;标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;分析试剂标准品;新品;标准品 -中药标准品;其它萜类;标准品，对照品

Mol文件:

17086-76-9.mol

熔点 

164～166℃

沸点 

735.2±60.0 °C(Predicted)

密度 

1.31±0.1 g/cm3(Predicted)

储存条件 

Keep in dark place,Inert atmosphere,2-8°C

酸度系数(pKa)

14.12±0.70(Predicted)

生物活性

Cyasterone，一种天然的 EGFR 抑制剂，主要分离自 Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可用于抗人类肿瘤的相关研究。

靶点

IC50: EGFR

体外研究

Cyasterone exerts cytotoxicity on multiple cell lines: HeLa (IC 50 =77.24 μg/ml); HepG-2 (IC 50 =52.03 μg/ml); MCF-7 (IC 50 =82.07 μg/ml) and MCF-7 (IC 50 =82.07 μg/ml). And It has none cytotoxicity (IC 50 >400 μg/ml) on 3 types of carcinoma (HT-29, Caco-2, T47D) and 1 type of normal (NIH 3T3) cell lines. Cyasterone (0-60 μg/ml; 48 hours) causes a significantly decreasing of the cell proliferation. It inhibits cell growth as a dose-dependent manner, exhibits IC 50 values of 38.50 μg/ml and 32.96 μg/ml, respectively. Cyasterone (0-60 μg/ml; 24 hours) decreases p-EGFR, p-MEK, and p-mTOR as a dose-dependent manner in A549 cells, it affects the MAPK signaling pathway activities. Cell Viability Assay Cell Line: A549 cells and MGC823 cells Concentration: 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml Incubation Time: 24 hours Result: Inhibited cell proliferation as a dose-dependent manner. Western Blot Analysis Cell Line: A549 cells Concentration: 0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml Incubation Time: 24 hours Result: Surpressed p-EGFR, p-MEK, and p-mTOR expression.

Cell Line:

A549 cells and MGC823 cells

Concentration:

0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml

Incubation Time:

24 hours

Result:

Inhibited cell proliferation as a dose-dependent manner.

Cell Line:

A549 cells

Concentration:

0 μg/ml, 20 μg/ml, 40 μg/ml, 60 μg/ml

Incubation Time:

24 hours

Result:

Surpressed p-EGFR, p-MEK, and p-mTOR expression.

体内研究

Cyasterone (intraperitoneal injection; 5 mg/kg, 10 mg/kg and 15 mg/kg; 21 days) has anti-proliferation effect in vivo and inhibits MGC823 cells xenografted tumor growth in vivo with few changes in body weights. Animal Model: MGC823 xenograft tumor in BALB/C-nu mice Dosage: 5 mg/kg, 10 mg/kg and 15 mg/kg Administration: Intraperitoneal injection Result: Inhibited MGC823 xenograft tumor growth in vivo.

Animal Model:

MGC823 xenograft tumor in BALB/C-nu mice

Dosage:

5 mg/kg, 10 mg/kg and 15 mg/kg

Administration:

Intraperitoneal injection

Result:

Inhibited MGC823 xenograft tumor growth in vivo.

化学性质 

白色结晶，溶于甲醇、乙醇、DMSO，来源于川牛膝CyathulaofficinalisKuan的干燥根。

用途 

杯苋甾酮有抗生育，活血，利胆，降脂的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:养血舒筋, 祛风除湿。

安全说明 

24/25

海关编码 

29322090