金石蚕苷

中文名称:

金石蚕苷

中文同义词:

金石蚕苷;金石蚕甙对照品,;金石蚕苷, 来源于广东紫珠;金石蚕甙;金石蚕苷(标准品);金石蚕苷 (金石蚕甙);POLIUMOSIDE 金石蚕苷

英文名称:

2-(3,4-Dihydroxyphenyl)ethyl 3-O,6-O-bis(α-L-rhamnopyranosyl)-4-O-[(E)-3-(3,4-dihydroxyphenyl)propenoyl]-β-D-glucopyranoside

英文同义词:

2-(3,4-Dihydroxyphenyl)ethyl 3-O,6-O-bis(α-L-rhamnopyranosyl)-4-O-[(E)-3-(3,4-dihydroxyphenyl)propenoyl]-β-D-glucopyranoside;Poliumoside;[6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-2-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate;6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-4-((3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)me;Poliumoside, 98%, from Callicarpa kwangtungensis Chun;O-6-Deoxy-alpha-L-mannopyranosyl-(1-3)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-6)]-beta-D-glucopyranoside 2-(3,4-dihydroxyphenyl)ethyl 4-[3-(3,4-dihydroxyphenyl)-2-propenoate];β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[6-deoxy-α-L-mannopyranosyl-(1→6)]-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

CAS号:

94079-81-9

分子式:

C35H46O19

分子量:

770.73

EINECS号:

相关类别:

对照品;植提标准品;中药对照品;标准品;植物提取物;标准品-对照品;分析试剂标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;精细化工;标准品-中药标准品;标准品 -中药标准品;其它酚类;标准品，对照品

Mol文件:

94079-81-9.mol

沸点 

1023.2±65.0 °C(Predicted)

密度 

1.62

酸度系数(pKa)

9.31±0.10(Predicted)

生物活性

Poliumoside对于晚期糖基化终产物的形成有显著抑制作用，IC50值为19.69 µM。 在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside对rat lens aldose reductase(RLAR)表现出抑制作用，IC50值为8.47 µM。

靶点

Target Value RLAR () 8.47 μM

Target

Value

RLAR ()

8.47 μM

体外研究

Poliumoside inhibits AGE formation and RLAR, with IC 50 s of 19.69, and 8.47 μM, respectively. Poliumoside (5-30 μM; 3 h) inhibits AAPH-induced hemolysis of rat red blood cells in vitro. Poliumoside (12.5-100 μM; pretreated 2 h) inhibits the release of TNF-α and IL-6 in LPS-induced RAW 264.7 cells.

体内研究

Poliumoside inhibits vessel dilation in larval zebrafish.

化学性质 

类白色结晶粉末，溶于水，来源于广东紫珠。

用途 

金石蚕苷具有抗菌消炎抗病毒作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:散瘀止血，消肿止痛。 叶:用于吐血，咯血，衄血，便血；外用治疗外伤出血。

海关编码 

29389090