中文同义词:
羟基芍药苷;氧化芍药苷(标准品);氧化芍药苷;氧化芍药苷?, >98%;氧化芍药苷(羟基芍药苷)对照品,;羟基芍药苷(氧化芍药苷);氧化芍药苷,羟基芍药苷(标准品);OXYPAEONIFLORIN 氧化芍药苷
英文同义词:
oxypaeoniflora;oxypaeoniflorin;[[(1aR)-3aβ,5,5aβ,5b-Tetrahydro-5β-hydroxy-5bβ-[[(4-hydroxybenzoyl)oxy]methyl]-2-methyl-2α,5-methano-3,4-dioxa-1H-cyclobuta[cd]pentalen]-1aβ(2H)-yl]β-D-glucopyranoside;Nsc258310;Oxypeoniflorin;Oxypaeoniflorin, >98%;β-D-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-tetrahydro-5-hydroxy-5b-[[(4-hydroxybenzoyl)oxy]methyl]-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl
相关类别:
对照品;植提标准品;标准品-对照品;中药对照品;标准品;植物提取物;The group of Paeoniflorin;芍药苷系列;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;标准品 -中药标准品;其它萜类;标准品,对照品
沸点
737.1±60.0 °C(Predicted)
密度
1.71±0.1 g/cm3(Predicted)
酸度系数(pKa)
8.16±0.15(Predicted)
应用
氧化芍药苷细胞毒性实验得知,其半数细胞毒性浓度 CC50 为 250.0μg/ml,质量浓度 200.0μg/ml 以下无细胞毒性,且 200.0μg/ml 氧化芍药苷对泡沫细胞胆固醇流出有明显作用.选取 200.0μg/ml 作为实验浓度。与 apoA-1 组比较,氧化芍药苷处理组胆固醇流出率增加 26%,提示氧化芍药苷有促进泡沫细胞胆固醇流出作用。进一步采用激光共聚焦显微镜观察氧化芍药苷处理的泡沫细胞内 ADFP 的表达变化。ADFP 是一种脂肪分化相关蛋白,是 apoA-1 介导的胆固醇流出通路中的转运囊泡的组成部,是 THP-1 巨噬细胞脂质沉积和动脉粥样硬化病变的标志性物质。共聚焦显微镜观察到 ac-LDL 泡沫细胞组有大量 ADFP 红色荧光蛋白表达,且在整个细胞内点状分布,apoA-1 组及氧化芍药苷处理组红色荧光相 继减弱且多集中于细胞膜边缘位置。同时,采用 Western blot 方法分析泡沫细胞内 ADFP 的表达变化,氧化芍药苷处理后 ADFP 表达量较 apoA-1 组降 低 28%。ADFP 的镜下观察与 Western blot 实验结果均提示,氧化芍药苷具有促使泡沫细胞胆固醇流出的作用。 此外,芍药苷类化合物包括氧化芍药苷在制备治疗脓毒症药物中的应用。
生物活性
Oxypaeoniflorin 是一种抗氧化剂,是从 Paeoniae 中分离得到的单萜糖苷化合物。Oxypaeoniflorin 具有神经保护和抗炎作用。
体外研究
Oxypaeoniflorin (OPA; 0.1-10 µM; 8 hours) obviously reversed the hypoxia/reoxygenation (H/R)-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Oxypaeoniflorin inhibits apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells.
Oxypaeoniflorin (0-30 μM) attenuates inflammatory effects via regulation of the toll-like receptor (TLR), extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases signaling pathways in LPS-stimulated RAW264.7 cells.
体内研究
Oxypaeoniflorin (OPA; 10-40 mg/kg; intragastrical administration; every day; for 30 days) treatment significantly reduces disruption of cardiac function and improves the indicators of ejection fraction (EF) and fractional shortening (FS). Oxypaeoniflorin significantly reduces the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT).
Animal Model: C57BL/6 male mice (6-8 weeks of age, 20-25 g) bearing myocardial ischemia/reperfusion (MI/R) injury
Dosage: 10 mg/kg, 20 mg/kg, 40 mg/kg
Administration: Intragastrical administration; every day; for 30 days
Result: Significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS).
Animal Model:
C57BL/6 male mice (6-8 weeks of age, 20-25 g) bearing myocardial ischemia/reperfusion (MI/R) injury
Dosage:
10 mg/kg, 20 mg/kg, 40 mg/kg
Administration:
Intragastrical administration; every day; for 30 days
Result:
Significantly reduced disruption of cardiac function and improved the indicators of ejection fraction (EF) and fractional shortening (FS).
化学性质
白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于牡丹皮、芍药、赤芍。
用途
羟基芍药苷具有抑制副交感神经兴奋、降低平滑肌张力和抑制其运动的作用。
用途
用于含量测定/鉴定/药理实验等
药理药效:有抗炎镇痛、调节免疫、治疗风湿性关节炎等作用