中文同义词:
氟氯西林钠(标准品);氟氯西林钠(无菌);氟氯西林钠(注射级);氟氯西林钠(口服);(2S,5R,6R)-6-[[3-(2-氯-6-氟苯基)-5-甲基-1,2-恶唑-4-甲酰]氨基]-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠盐;氟氯西林钠;氟氯西林钠 EP标准品
英文名称:
Flucloxacillin sodium
英文同义词:
(2s-(2-alpha,5-alpha,6-beta))-al;sodium [2S-(2alpha,5alpha,6beta)]-6-[[[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;Flucloxacillin sodium BP98;3-dimethyl-7-oxo-henyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-monosodiums;4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((3-(2-chloro-6-fluorop;5-methyl-3-(2-chloro-6-fluorophenyl)-4-isoxazolylpenicillinsodium;floxacillinsodium;floxapensodium
相关类别:
医药原料药;医药原料;分析标准品;氟氯西林钠;生命科学标准品;青霉素类;医用原料;API;APIs;Intermediates Fine Chemicals;Pharmaceuticals;Peptide Synthesis/Antibiotics;Isoquinolines ,Quinolines ,Quinaldines;原料药;医用原料;原料;医药原料药 科研原料;化学试剂
溶解度
H2O: soluble20mg/mL, clear
InChIKey
OTEANHMVDHZOPB-SLINCCQESA-M
CAS 数据库
1847-24-1(CAS DataBase Reference)
生物活性
Flucloxacillin sodium是高活性的抗革兰氏阳性和革兰氏阴性菌的抗生素。
体内研究
The serum elimination half-life of flucloxacillin is 1.31-1.39 hours, and six hours after administration of a single 250 mg dose the serum concentration of flucloxacillin is 0.46 micrograms/mL. Oral flucloxacillin does not affect sweat electrolytes and is not a contraindication to sweat testing. Flucloxacillin has been reported to be metabolized in man to the penicilloic acid, the antibacterially active 5-hydroxymethyl derivative and the penicilloic acid of the 5-hydroxymethyl derivative. The metabolism of flucloxacillin in the rat is similar.
化学性质
白色或类白色结晶性粉末，易溶于水(1：1)，溶于乙醇(1：12)或丙酮(1：12)。
用途
主要应用于葡萄球菌所致的各种周围感染，但对耐甲氧西林的金黄色葡萄球菌(MR-SA)感染无效
毒性
LD50 oral in rabbit: > 8gm/kg
