中文同义词:
蒽林;地蒽酚;二羟蒽酚;去甲苛桠素;1,8,9-三羟基蒽|1,8,9-TRIHYDROXYANTHRACENE;9-三羟基蒽;1,8,9-蒽三酚(停产);蒽三酚杂质
英文同义词:
DITHRANOL;9-anthrol;DITHRANOL, 97+%;1,8,9-ANTHRACENETRIOL, PGE. WITH 10 X 10 MG;1,8,9-Trihydroxyanthracene, 97+%;Anthraforte;Micanol;Psorider
相关类别:
化工原料;医药化工类;原料药;农业原料;原料;皮肤类甾体激素;医药原料药-科研原料;Intermediates Fine Chemicals;生化试剂;ANTRADERM;医药中间体;碳水化合物;Skin drugs, treatment of psoriasis;API;小分子抑制剂;医药原料;皮肤科用原料药;中药对照品;医用原料;医药原料药;陕西林奈主打产品;Aromatic Phenols;Pharmaceuticals
沸点
464.1±45.0 °C(Predicted)
密度
1.419±0.06 g/cm3(Predicted)
溶解度
Practically insoluble in water, soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
酸度系数(pKa)
7.16±0.20(Predicted)
水溶解性
Insoluble in water. Soluble in acetic acid, chloroform (20 mg/mL), acetone, benzene, solutions of alkali hydroxides, fixed oil. Slightly soluble in 95% ethanol, alcohol, ether, and glacial acetic acid.
稳定性
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
NUZWLKWWNNJHPT-UHFFFAOYSA-N
CAS 数据库
1143-38-0(CAS DataBase Reference)
(IARC)致癌物分类
3 (Vol. 13; Sup 7) 1987
EPA化学物质信息
Dithranol (1143-38-0)
生物活性
Dithranol (Anthralin) 是一种蒽醌衍生物，具有较强的抗银屑病作用。Dithranol 能抑制 DNA 的复制和修复。
体外研究
Dithranol (1.1 μM) inhibits replication in T98G cells by 50%.
Dithranol (0.1-0.5 μg/mL; 2-4 hours) increases the mRNA production of interleukin-10 receptors in a concentration dependent manner in HaCaT cells.
RT-PCR
Cell Line: HaCaT cells
Concentration: 0.1 μg/mL, 0.25 μg/mL, 0.5 μg/mL
Incubation Time: 2 hours, 4 hours
Result: Increased the mRNA production of interleukin-10 receptors in HaCaT cells.
Concentration:
0.1 μg/mL, 0.25 μg/mL, 0.5 μg/mL
Incubation Time:
2 hours, 4 hours
Result:
Increased the mRNA production of interleukin-10 receptors in HaCaT cells.
