银杏内酯 C
中文名称:
银杏内酯 C
中文同义词:
白果苦内酯C,1Β,7Β-二羟基银杏内酯A;银杏内酯C(白果苦内酯C,1Β,7Β-二羟基银杏内酯A);GINKGOLIDE C 银杏内酯C;银杏内酯C(分析标准品);银杏内酯 C, 来源于银杏;杏内酯 C;银杏内酯C(标准品);7Β-二羟基银杏内酯A)
英文名称:
Ginkgolide C
英文同义词:
GINKGOLIDE C;1,7-DIHYDROXY-GINKGOLIDE A;(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3,2:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione;Gingkolide C;bn52022;GinkgolideA,1,7-dihydroxy-, (1α,7β)-;CGinkgolid;Ginkgolide C, 98%, from Ginkgo biloba L.
CAS号:
15291-76-6
分子式:
C20H24O11
分子量:
440.4
EINECS号:
相关类别:
标准品，对照品;标准品-中药标准品;中药对照品;标准品;生化试剂;对照品,标准品;分析标准品;Pharmaceuticals;植物提取物;chemical reagent;pharmaceutical intermediate;对照品;植提标准品;中药标准品;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物;标准品-对照品;二萜;标准品 -中药标准品;分析试剂-标准品;Saponins;Intermediates Fine Chemicals;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol文件:
15291-76-6.mol
熔点
>3000 (dec)
比旋光度
D24 -14.7° (c = 1 in ethanol)
沸点
813.8±65.0 °C(Predicted)
密度
1.72±0.1 g/cm3(Predicted)
储存条件
Sealed in dry,Store in freezer, under -20°C
酸度系数(pKa)
10.88±0.70(Predicted)
形态
neat
生物活性
Ginkgolide C 是从银杏叶中分离到的黄酮类物质，具有多种生物功能，可以减少血小板聚集，改善阿尔兹海默症等。
靶点
AMPK
MMP-9
Human Endogenous Metabolite
Sirtuin
AMPK
MMP-9
体外研究
Ginkgolide C (3-100 μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24 h treatment. Ginkgolide C (10-100 μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets.
化学性质
白色结晶体，易溶于甲醇，来源于银杏叶。
用途
银杏内酯C对治疗心、脑血管疾病有很好的辅助作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:银杏内酯C对治疗心、脑血管疾病有很好的辅助作用。
安全说明
22-24/25
WGK Germany
3
F
10-21
海关编码
29322090
