中文同义词:
GI银杏内酯A;银杏苦内酯A;银杏内酯A(标准品);银杏内酯 A 来源于银杏 叶;白果苦内酯 A;银杏内酯 A;银杏内酯A;银杏内酯 A, 来源于银杏
英文同义词:
1,7-DIDEOXYGINKGOLIDE C;BN-52020;GINKGOLIDE A;GINKGOLIDE A, GINKGO BILOBA L;PRIMULIC ACID 1;GINKGOLIDE A FROM GINKGO LEAVES;lide A;Ginkgolide A, 98%, from Ginkgo biloba L.
相关类别:
小分子抑制剂;小分子抑制剂，天然产物;标准品-对照品;其他生化试剂;中药对照品;标准品;生化试剂;对照品,标准品;分析标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;对照品;植提标准品;中药标准品;标准品，对照品;标准品-中药标准品;标准品 -中药标准品;二萜;分析试剂-对照品;Saponins;Intermediates Fine Chemicals;Pharmaceuticals;EstersChemical Class;Herbal DrugsAnalytical Standards;Heterocyclics;KetonesChromatography;Oxygen containing;Analytical Standards;Chemical Class;Life Sciences Standards;Natural Compounds;Natural CompoundsChemical Class;GNutrition Research;Alphabetic;Biochemicals Found in Plants;Isoprenoid/terpenoid;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
比旋光度
D24 -53.4° (c = 1 in ethanol)
沸点
710.1±60.0 °C(Predicted)
密度
1.56±0.1 g/cm3(Predicted)
储存条件
Inert atmosphere,Store in freezer, under -20°C
酸度系数(pKa)
11.45±0.70(Predicted)
最大波长(λmax)
219nm(EtOH)(lit.)
InChIKey
FPUXKXIZEIDQKW-VKMVSBOZSA-N
CAS 数据库
15291-75-5(CAS DataBase Reference)
生物活性
Ginkgolide A (BN52020) 是银杏的提取物，是γ-氨基丁酸(GABA)拮抗剂，Ki为14.5 μM。
靶点
Target Value
GABA receptor 14.5 μM(Ki)
体外研究
Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. Ginkgolide A (BN-52020) failed to affect apoptotic damage neither in serum-deprived nor in staurosporine-treated neurons.
体内研究
Ginkgolide A significantly shortened the sleeping time in anesthetized mice.
化学性质
白色结晶体，易溶于甲醇、丙酮，不溶于水，来源于银杏叶。
用途
用于含量测定/鉴定/药理实验等。
药理药效:银杏内酯A对应激性溃疡有显著的预防作用,对胆碱能损伤记忆功能具有恢复作用，能防止ChAT活力降低,缓解和改善心肌缺血作用，可阻抑DAD的发生,并有抗焦虑作用。
