中文名称:

2-(4,4-二氟-1-哌啶基)-6-甲氧基-N-[1-异丙基-4-哌啶基]-7-[3-(1-吡咯烷基)丙氧基]-4-喹唑啉胺

中文同义词:

2-(4,4-二氟-1-哌啶基)-6-甲氧基-N-[1-异丙基-4-哌啶基]-7-[3-(1-吡咯烷基)丙氧基]-4-喹唑啉胺;G9A和GLP抑制剂(UNC0642);化合物UNC0642

英文名称:

UNC-0642

英文同义词:

UNC 0642;UNC0642;UNC-0642;2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine;UNC0642, 2-(4,4-Difluoro-1-piperidinyl)-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine;UNC-0642;UNC0642;UNC 0642

CAS号:

1481677-78-4

分子式:

C29H44F2N6O2

分子量:

546.7

EINECS号:

相关类别:

抑制剂;细胞生物学试剂

Mol文件:

1481677-78-4.mol

沸点 

679.2±65.0 °C(Predicted)

密度 

1.23±0.1 g/cm3(Predicted)

储存条件 

2-8°C

形态

powder

酸度系数(pKa)

10.06±0.20(Predicted)

颜色

white to beige

生物活性

UNC0642是有效，选择性的赖氨酸甲基转移酶 G9a 和 GLP 抑制剂， 抑制 G9a 的IC50 值小于2.5 nM。

靶点

IC50: <2.5 nM (G9a)

体外研究

UNC0642 displays high in vitro and cellular potency, low cell toxicity, and excellent selectivity. UNC0642 is competitive with the peptide substrate and non-competitive with the cofactor SAM. The K i of UNC0642 is determined to be 3.7±1 nM. UNC0642 displays high in vitro potency for GLP (IC 50 < 2.5 nM), similar to G9a. UNC0642 is more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels. UNC0642 exhibits high potency at reducing the H3K9me2 mark, low cell toxicity, and good separation of functional potency and cell toxicity in a number of cell lines. It reduces clonogenicity in PANC-1 cells, a pancreatic carcinoma cell line.

体内研究

A single intraperitoneal (IP) injection (5 mg/kg) of UNC0642 results in a plasma C max (maximum concentration) of 947 ng/mL and an AUC (area under the curve) of 1265 hr*ng/mL.

WGK Germany 

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