中文名称:

羟基嘌呤

中文同义词:

1H-吡唑并[3,4-D]嘧啶-4,6(5H,7H)-二酮;4,6-二羟基吡唑并[3,4-D]嘧啶;4,6-二羟基吡唑啉[3,4-D]嘧啶, 98+%;奥昔嘌醇;氧嘌醇;氧嘌呤醇;4,6-二羟基吡唑啉[3,4-D]嘧啶;羟基嘌呤

英文名称:

Oxipurinol

英文同义词:

4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%;4,6-Dihydropyrazolo Pyrimidine;4,6-Dihydroxypyrazolo[3,4-d]pyrimidine,99%;4,6-Dihydroxypyrazolo[3,4-d]pyriMidine (Oxypurinol);OXYPURINOL;OXIPURINOL;4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine;4,6-Dioxopyrazolo[3,4-d]pyrimidine

CAS号:

2465-59-0

分子式:

C5H4N4O2

分子量:

152.11

EINECS号:

219-570-9

相关类别:

小分子抑制剂;对照品;Heterocycles, Metabolites Impurities, Nucleotides, Bases Related Reagents, Pharmaceuticals, Intermediates Fine Chemicals;Heterocycles;Intermediates Fine Chemicals;Metabolites Impurities;Pharmaceuticals;Pyridines, Pyrimidines, Purines and Pteredines;Nucleotides and Nucleosides;Bases Related Reagents;Nucleotides;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides

Mol文件:

2465-59-0.mol

熔点 

300 °C

沸点 

274.55°C (rough estimate)

密度 

1.637

折射率 

1.8500 (estimate)

储存条件 

Sealed in dry,Room Temperature

溶解度 

Soluble in DMSO.

酸度系数(pKa)

pKa 7.7 (Uncertain)

形态

Powder

颜色

Light yellow

BRN 

139956

CAS 数据库

2465-59-0(CAS DataBase Reference)

EPA化学物质信息

Oxypurinol (2465-59-0)

生物活性

Oxopurinol (Oxipurinol) 是 Allopurinol 的主要活性代谢产物，是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Oxipurinol 可用于调节血尿酸水平，有潜力用于痛风的研究。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

Allopurinol is rapidly metabolized (half-life approximately 1 h) to its active metabolite oxypurinol. Oxypurinol is an inhibitor of xanthine oxidoreductase and has a considerably longer elimination half-life (approximately 23 h).

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

36

WGK Germany 

3

HazardClass 

IRRITANT

海关编码 

29335990