中文同义词:
N1-羟基-N3-(2-苯基乙基)-1,3-苯二甲酰胺;HDAC抑制剂(BRD73954)
英文同义词:
N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide;BRD73954;N1-hydroxy-N3-phenethylisophthalamide;N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954;BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide;BRD-73954;BRD 73954;CS-1777;1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-
相关类别:
细胞生物学试剂;小分子抑制剂，天然产物;抑制剂;Inhibitors
密度
1.245±0.06 g/cm3(Predicted)
储存条件
Inert atmosphere,2-8°C
酸度系数(pKa)
8.56±0.10(Predicted)
生物活性
BRD73954是一种有效的选择性 HDAC 抑制剂，对HDAC6 和 HDAC8的 IC50 分别为 36 nM 和 120 nM。
体外研究
As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation.
