中文名称:

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide

中文同义词:

(3R)-N-[5-氯-4-(5-氟-2-甲氧基苯基)-2-吡啶基]-3-哌啶甲酰胺;CDK抑制剂(CDK-IN-2)

英文名称:

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide

英文同义词:

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide;(3R)-N-[5-Chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-3-piperidinecarboxamide;Novartis;CDK inhibitor II;CDK-IN-2;(R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide;CDK inhibitor 2;3-Piperidinecarboxamide, N-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (3R)-

CAS号:

1269815-17-9

分子式:

C18H19ClFN3O2

分子量:

363.81

EINECS号:

604-604-1

相关类别:

细胞生物学试剂

Mol文件:

1269815-17-9.mol

沸点 

525.6±50.0 °C(Predicted)

密度 

1.300

酸度系数(pKa)

12.16±0.20(Predicted)

生物活性

CDK-IN-2是CDK特异性抑制剂，IC50值为<8 nM。

靶点

CDK9/cyclinT1 8 nM (IC 50 )

CDK9/cyclinT1 8 nM (IC 50 )