中文名称:

GNE 477

中文同义词:

双重PI3K/MTOR抑制剂(GNE-477);化合物GNE 477

英文名称:

GNE 477

英文同义词:

GNE 477;5-[7-Methyl-4-(Morpholin-4-yl)-6-[(4-Methylsulfonylpiperazin-1-yl)Methyl]thieno[3,2-d]pyriMidin-2-yl]pyriMidin-2-aMine;5-[7-Methyl-4-(morpholin-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine GNE 477;5-(7-Methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-;CS-1884;2-Pyrimidinamine, 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-;5-(7-Methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

CAS号:

1032754-81-6

分子式:

C21H28N8O3S2

分子量:

504.63

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1032754-81-6.mol

密度 

1.51±0.1 g/cm3(Predicted)

酸度系数(pKa)

4.22±0.10(Predicted)

生物活性

GNE-477是有效的PI3K/mTOR抑制剂，对PI3Kα的IC50值为4 nM，对mTOR的Kiapp值为21 nM。

靶点

Target Value PI3Kα (Cell-free assay) 4 nM mTOR (Cell-free assay) 21 nM(Ki app) mTOR (Cell-free assay) 21 nM(Ki app)

Target

Value

PI3Kα (Cell-free assay)

4 nM

mTOR (Cell-free assay)

21 nM(Ki app)

mTOR (Cell-free assay)

21 nM(Ki app)