中文名称:

雷公藤次碱

中文同义词:

雷公藤次碱;雷公藤次碱(标准品);WILFORINE 雷公藤次碱;雷公藤灵

英文名称:

WILFORINE

英文同义词:

WILFORINE;(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione,10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-,(8R,9R,10R,11S,1;(8α)-8-(Acetyloxy)-2-O-benzoyl-2-O-deacetyl-8-deoxoevonimine;(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-m;26-Deoxywilfordine;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione, 10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-, (8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-;Evonimine, 8-(acetyloxy)-O2-benzoyl-O2-deacetyl-8-deoxo-, (8α)-

CAS号:

11088-09-8

分子式:

C43 H49 N O18

分子量:

867.85

EINECS号:

相关类别:

雷公藤系列;植物提取物;对照品，标准品，含量测定，药理研究;标准品;对照品;中药对照品;对照品-中药对照品;reagent;standard substance;标准品 -中药标准品;倍半萜;标准品，对照品

Mol文件:

11088-09-8.mol

熔点 

158-163℃

沸点 

871.5±65.0 °C(Predicted)

密度 

1.41

酸度系数(pKa)

11.70±0.70(Predicted)

生物活性

Wilforine (WR) 是在wilfordii植株中发现的倍半萜吡啶生物碱，可显著地抑制 P-glycoprotein (P-gp) 的外排活性。

靶点

Target Value P-gp ()

Target

Value

P-gp ()

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于雷公藤，山海棠。

用途 

雷公藤次碱具有杀虫，抗肿瘤，抗炎的作用。

用途 

用于含量测定/鉴定/药理实验等

毒性

LD50 intraperitoneal in mouse: 418mg/kg