中文名称:

429653-73-6

中文同义词:

G蛋白偶联RHO GEFS抑制剂(Y16);化合物Y16

英文名称:

Y16

英文同义词:

Y16;4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione;Y16, >98%;Y16, 429653-73-6;3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-

CAS号:

429653-73-6

分子式:

C24H20N2O3

分子量:

384.43

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

429653-73-6.mol

密度 

1.273±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

DMSO: soluble5mg/mL, clear (warmed)

形态

powder

酸度系数(pKa)

8.84±0.20(Predicted)

颜色

, faint yellow to dark orange

生物活性

Y16是G蛋白偶联Rho GEFs抑制剂。它能阻止LARG和Rho的结合，Kd值为80 nM。

靶点

Target Value RhoGEFs ()

Target

Value

RhoGEFs ()

体外研究

Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA. Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA. Cell Viability Assay Cell Line: NIH 3T3 cells Concentration: 10 μΜ, 30 μΜ Incubation Time: 24 hours Result: Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA. Western Blot Analysis Cell Line: NIH 3T3 cells Concentration: 10 μΜ, 30 μΜ Incubation Time: 24 hours Result: Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.

Cell Line:

NIH 3T3 cells

Concentration:

10 μΜ, 30 μΜ

Incubation Time:

24 hours

Result:

Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA.

Cell Line:

NIH 3T3 cells

Concentration:

10 μΜ, 30 μΜ

Incubation Time:

24 hours

Result:

Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.

危险品标志 

N

危险类别码 

50/53

安全说明 

60-61

危险品运输编号 

UN 3077 9 / PGIII

WGK Germany 

3