中文名称:

PDK1 抑制剂

中文同义词:

PDK1 抑制剂;PDK1抑制剂(PDK1 INHIBITOR)

英文名称:

PDK1 inhibitor

英文同义词:

PDK1 inhibitor;PDK1 inhibitor 7;1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-;MP7;2-dihydro-2-oxo-;3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1;4-difluorophenyl)methyl]-N-[(1R)-2-[(2

CAS号:

1001409-50-2

分子式:

C28H22F2N4O4

分子量:

516.5

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1001409-50-2.mol

沸点 

724.4±60.0 °C(Predicted)

密度 

1.398

酸度系数(pKa)

11.48±0.20(Predicted)

生物活性

MP7 (PDK1 inhibitor) 是一种磷酸肌醇依赖性激酶-1 (PDK1) 抑制剂。

靶点

PDK1

体外研究

Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC 50 values in the micromolar range.