中文名称:

SJB2-043

中文同义词:

2-苯基萘并[2,3-D]恶唑-4,9-二酮;USP1/UAF1复合体抑制剂(SJB2-043)

英文名称:

SJB2-043

英文同义词:

SJB2-043;2-Phenylnaphth[2,3-d]oxazole-4,9-dione;2-phenylbenzo[f][1,3]benzoxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-phenyl-

CAS号:

63388-44-3

分子式:

C17H9NO3

分子量:

275.26

EINECS号:

相关类别:

细胞生物学试剂;抑制剂

Mol文件:

63388-44-3.mol

熔点 

>290℃

沸点 

495.0±48.0 °C(Predicted)

密度 

1.373±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,Room Temperature

酸度系数(pKa)

-3.87±0.20(Predicted)

用途

SJB2-043是有效的USP1抑制剂，可抑制天然USP1/UAF1的活性，IC50为544 nM。

生物活性

SJB2-043 是一种有效的 USP1 的抑制剂，可抑制天然 USP1/UAF1 的活性，对应的IC50值为544 nM。

靶点

Target Value USP1-UAF1 (Cell-free assay) 544 nM

Target

Value

USP1-UAF1 (Cell-free assay)

544 nM

体外研究

SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC 50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner.