中文名称:

GSK-3Β抑制剂(CP21R7)

中文同义词:

3-(3-氨基苯基)-4-(1-甲基-1H-吲哚-3-基)吡咯-2,5-二酮;GSK-3Β抑制剂(CP21R7);化合物CP21R7

英文名称:

CP21R7(CP21)

英文同义词:

3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione;CP21R7(CP21);CP21R7;3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;CS-2352;CP21 (CP21R7);3-(3-aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-

CAS号:

125314-13-8

分子式:

C19H15N3O2

分子量:

317.34

EINECS号:

相关类别:

细胞生物学试剂;抑制剂

Mol文件:

125314-13-8.mol

沸点 

627.4±55.0 °C(Predicted)

密度 

1.37±0.1 g/cm3(Predicted)

储存条件 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

酸度系数(pKa)

7.79±0.60(Predicted)

生物活性

CP21R7 (CP21) 是一种有效的、选择性的GSK-3β抑制剂，能有效激活经典Wnt信号通路。

靶点

Target Value GSK-3β (Cell-free assay)

Target

Value

GSK-3β (Cell-free assay)

体外研究

CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC 50 of 1.8 nM; the IC 50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.