中文同义词:
4-溴-2-氟苯甲酸;4-溴-2-氟苯甲酸4-BROMO-2-FLUOROBENZOIC ACID;4-溴-2-氟苯甲酸 25G;4-溴-2-氟苯甲酸(2-氟-4-溴苯甲酸);邻氟对溴苯甲酸;4-溴-2-氟苯甲酸, 98+%;恩杂鲁胺EP杂质A;4-溴-2-氟苯甲酸(CAS号:112704-79-7)
英文名称:
4-Bromo-2-fluorobenzoic acid
英文同义词:
4-Bromo-2-fluorobenzoic;4-Bromo-2-fluorobenzoic acid 98%;4-Bromo-2-fluorobenzoicacid98%;Enzalutamide Impurity 13;4-Bromo-2-fluorobenzoic acid ,99%;4-BroMo-2-fluorobenzoic acid, 98% 1GR;4-BroMo-2-fluorobenzoic acid, 98% 5GR;4 - broMine - 2 - fluoro benzoic acid
相关类别:
芳烃;苯环类中间体;医药中间体;苯酸系列;液晶;中间体;有机酸;Fluorin-contained Benzoic acid series;含氟苯甲酸;blocks;Bromides;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series;Fluorine series;对照品-杂质对照品;标准品;化工中间体;合成材料中间体;有机化工原料;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides Salts;Benzoic acid;Fluorobenzene;Acids Esters;Bromine Compounds;Fluorine Compounds;Benzoic Acids (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials
沸点
289.4±25.0 °C(Predicted)
密度
1.7218 (rough estimate)
储存条件
Sealed in dry,Room Temperature
溶解度
Solubility in methanol, very faint turbidity.
酸度系数(pKa)
3.04±0.10(Predicted)
InChIKey
ZQQSRVPOAHYHEL-UHFFFAOYSA-N
CAS 数据库
112704-79-7(CAS DataBase Reference)
EPA化学物质信息
Benzoic acid, 4-bromo-2-fluoro- (112704-79-7)
应用
4-溴-2-氟苯甲酸是一种有机中间体，可由2-氟-4-溴甲苯为原料，通过氧化反应制备得到。有文献报道其可用于制备恩杂鲁胺中间体和维奈托克关键中间体。
制备
2-氟-4-溴甲苯25g(132.3mmol,1.0eq)，AIBN 521mg(3.2mmol,0.024eq)，Co(OAc)2·4H2O 1.6g(6.5mmol,0.049eq)，NaBr 449mg(4.4mmol,0.033eq)，溶于HOAc 250mL(10V)中，搅拌全溶待用，将反应盘管外浴温度升至130℃，用氧气调节盘管压力1.2MPa，进而开始打料，体系停留时间1.5h，氧气3～5eq。将体系直接泵入375mL纯化水中，用NaOH固体将体系pH调至12～14，用125mL MTBE萃取水相两次，水相再用浓HCl调pH至1，有大量固体析出，过滤得到目标产品25.5g，收率88％。1H-NMR(CDCl3)δ:7.38–7.42(m,2H),7.89(t,1H,J＝7.88)。
