衣霉素

中文名称:

衣霉素

中文同义词:

衣霉素复合物;衣霉素 来源于链霉菌属;TUNICAMYCIN FROM STREPTOMYCES SP. 来源于链霉菌 属;衣霉素(链霉菌属);TUNICAMYCIN 衣霉素;链病毒菌素;源于STREPTOMYCESLYSOSUPERFIUSNOV.SP.的链病毒菌素;衣霉素

英文名称:

TUNICAMYCIN

英文同义词:

Aids010655;Aids-010655;Nsc177382;TunicaMycin froM StreptoMyces lysosuperficus;TunicaMycin coMplex;InSolution? Tunicamycin,;TUNICAMYCIN, STREPTOMYCES IYSOSUPERFICUS;TUNICAMYCIN, STREPTOMYCES LYSOSUPERFICUS

CAS号:

11089-65-9

分子式:

C37H60N4O16

分子量:

816.89

EINECS号:

601-012-4

相关类别:

微生物代谢物;细胞信号和神经生物学;细胞生物学;抗生素;抗生素及抗病毒;抗生素、生物碱;生化试剂;对照品;化合物;NucleosidesMore...Close...;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics T-ZAntibiotics;AntifungalAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;AntiviralAntibiotics;Chemical Structure Class;Interferes with Protein SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;Spectrum of Activity;Signalling;antibiotic;化工原料

Mol文件:

11089-65-9.mol

熔点 

234-235℃ (decomposition)

比旋光度 

D20 +52° (c = 0.5 in pyridine)

闪点 

87℃

储存条件 

2-8°C

溶解度 

Soluble in methanol, ethanol, DMSO, or DMF

形态

White to off-white solid

敏感性 

Moisture Light Sensitive

BRN 

6888090

InChIKey

YJQCOFNZVFGCAF-WPTOCQRYSA-N

EPA化学物质信息

Tunicamycin (11089-65-9)

生物活性

Tunicamycin 是一种同源核苷抗生素的混合物, 可抑制 N-糖基化并阻断 GlcNAc 磷酸转移酶 (GPT)。Tunicamycin 引起细胞内质网 (ER) 中未折叠蛋白的积累并诱导 ER 应激，并导致 DNA 合成受阻和 G1 期细胞周期停滞。Tunicamycin 可抑制革兰氏阳性细菌，酵母，真菌和病毒，并具有抗癌活性。Tunicamycin 增加宫颈癌细胞中外泌体的释放。

体外研究

Tunicamycin (2 µg/mL; 24 hours; CD44+/CD24- and original MCF7 cells) treatment increases the spliced XBP-1, ATF6 nuclear translocation level and CHOP protein expression in CD44+/CD24- and original MCF7 cells. Tunicamycin-induced ER stress suppresses CD44+/CD24- phenotype cell subpopulation and in vitro invasion and accelerates tumorosphore formation. Under effect of Tunicamycin, the results show that inhibited invasion, increased cell death, suppressed proliferation and reduced migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture. Western Blot Analysis Cell Line: CD44+/CD24- and original MCF7 cells [1] Concentration: 2 µg/mL Incubation Time: 24 hours Result: Increased level of spliced XBP-1, ATF6 nuclear translocation and CHOP protein expression are detected in CD44+/CD24- and original MCF7 cells.

Cell Line:

CD44+/CD24- and original MCF7 cells [1]

Concentration:

2 µg/mL

Incubation Time:

24 hours

Result:

Increased level of spliced XBP-1, ATF6 nuclear translocation and CHOP protein expression are detected in CD44+/CD24- and original MCF7 cells.

体内研究

Tunicamycin (0.1 mg/kg or 0.5 mg/kg) treatment dramatically suppresses tumor growth in the CD133 +/- MHCC97L cells xenograft model (BALB/c ( nu/nu ) mice).

危险品标志 

T+,T

危险类别码 

28

安全说明 

28-37/39-45

危险品运输编号 

UN 3462 6.1/PG 2

WGK Germany 

3

RTECS号

YO7980200

F 

8-10-18-21

HazardClass 

6.1(a)

PackingGroup 

II

海关编码 

29419090