青霉素 V 钾

中文名称:

青霉素 V 钾

中文同义词:

3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸钾盐;青霉素V钾盐;青霉素V钾;青霉素V钾盐, 98%,HPLC;青霉素V钾、青霉素V/苯氧甲基青霉素;青霉素V钾盐 标准品;PENICILLIN V POTASSIUM SALT 青霉素V钾;3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫-1-氮杂双环

英文名称:

Penicillin V potassium salt

英文同义词:

Penicillin V potassium salt, Phenoxymethylpenicillinic acid potassium salt;PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT;PHENOXYMETHYLPENICILLIN K+ SALT;PHENOXYMETHYLPENICILLIN POTASSIUM;PHENOXYMETHYL PENICILLIN POTASSIUM SALT;PENICILLIN VK;PENICILLIN V POTASSIUM;PENICILLIN V POTASSIUM SALT

CAS号:

132-98-9

分子式:

C16H17KN2O5S

分子量:

388.48

EINECS号:

205-086-5

相关类别:

医药原料;化学试剂;抗感染药物;医药与生物化工;小分子抑制剂，天然产物;生命科学标准品;抗生素;青霉素类;小分子抑制剂;Inhibitors;抗生素类;医药原料药;生化试剂;原料;标准品 -中药标准品;原料药;医用原料;添加剂1;Peptide Synthesis/Antibiotics;Chiral Reagents;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;Sulfur Selenium Compounds;NULL;BEEPEN-VK;antibiotic

Mol文件:

132-98-9.mol

熔点 

197-202°C

比旋光度 

D25 +223° (c = 0.2)

密度 

1.40

储存条件 

2-8°C

溶解度 

Freely soluble in water, practically insoluble in ethanol (96 per cent).

形态

neat

颜色

Sol in water

水溶解性 

Soluble in water, dimethyl sulfoxide, and methanol.

BRN 

3899451

InChIKey

HCTVWSOKIJULET-LQDWTQKMSA-M

CAS 数据库

132-98-9(CAS DataBase Reference)

EPA化学物质信息

Penicillin V Potassium (132-98-9)

概述

青霉素V钾为青霉素类抗生素。抗菌谱与青霉素相同。对多数革兰阳性菌、革兰阴性球菌、个别革兰阴性杆菌（如嗜血杆菌属）、螺旋体和放线菌均有抗菌活性，但多数葡萄球菌菌株（>90%）包括金黄色葡萄球菌和凝固酶阴性葡萄球菌可产生β内酰胺酶使本品水解而失活。本品对大多数敏感菌株的活性较青霉素弱2～5倍。对产青霉素酶的菌株无抗菌作用。

生物活性

Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) 是一种口服活性抗生素。Penicillin V Potassium 可抑制链球菌，艰难梭菌和金黄色葡萄球菌的生长，可用于中耳炎，鼻窦炎，咽炎和扁桃体炎的研究。

体外研究

Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci , with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L. Penicillin V (0.002-8.0 mg/L) inhibits the growth of C. difficile , with a MIC 90 of 8 mg/L. Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus , with a MIC of 0.016 mg/L.

体内研究

Penicillin V (0.063-0.25 mg/kg; a single s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle. Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats. Penicillin V (2 mg/kg; a single s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L•h). Animal Model: Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus Dosage: 0.063, 0.13, 0.25 mg/kg Administration: A single s.c. Result: Decreased the number of CFU (1.34×10 7 counts/mL) compared to controls (3.5×10 7 counts/mL) at the dose of 0.25 mg/kg.

Animal Model:

Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus

Dosage:

0.063, 0.13, 0.25 mg/kg

Administration:

A single s.c.

Result:

Decreased the number of CFU (1.34×10 7 counts/mL) compared to controls (3.5×10 7 counts/mL) at the dose of 0.25 mg/kg.

用途 

用作抗生素

危险品标志 

Xn

危险类别码 

22-42/43

安全说明 

22-26-36/37-45

WGK Germany 

3

RTECS号

XH9275000

TSCA 

Yes

海关编码 

29411099

毒害物质数据

132-98-9(Hazardous Substances Data)

毒性

LD50 orally in rats: >1040 mg/kg (Goldenthal)