阿米卡星硫酸盐(5:9)

中文名称:

阿米卡星硫酸盐(5:9)

中文同义词:

阿米卡霉素硫酸;磺胺甲恶唑149022-22-0;硫酸阿米卡星149022-22-0;硫酸阿米卡星;硫酸阿米卡星(5:9);O-3-氨基-3-脱氧-Α-D-吡喃葡萄糖基-(1→6)-O-[6-氨基-6-脱氧-Α-D-吡喃葡萄糖基-(1→4)]-N1-[(2S)-4-氨基-2-羟基-1-氧丁基]-2-脱氧-D-链胺硫酸盐(5:9);阿米卡星硫酸盐(5:9)

英文名称:

Amikacin sulfate salt

英文同义词:

AMIKACIN SULFATE 1:1.8;Amikacin sulfate salt;(2S)-4-AMino-N-{(1R,2S,3S,4R,5S)-5-aMino-2-[(3-aMino-3-deoxy-a-D-glucopyranosyl)oxy]-4-[(6-aMino-6-deoxy-a-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanaMide sulfate (1:2);AMIKASIN SULFATE;Amikacin sulfate(5:9);AMIKACIN SULFATE SALT, AMINOGLYCOSID;mikacin disulfate salt;liusuanamukaxonm

CAS号:

149022-22-0

分子式:

C22H45N5O17S

分子量:

683.68

EINECS号:

254-648-6

相关类别:

医药原料;抗感染药物;医药与生物化工;原料药;化合物：原料药;医药兽药;医药原料药-科研原料;中间体;原料中间体-原料药;精细化工;医用原料;医用原料;兽药原料药

Mol文件:

149022-22-0.mol

储存条件 

2-8°C

溶解度 

H2O: soluble50mg/mL

形态

solid

颜色

white to off-white

InChIKey

HIBICIOPDUTNRR-BOEHXBESSA-N

生物活性

Amikacin sulfate (BAY 41-6551 sulfate) 是一种氨基糖苷类抗生素，也是一种卡那霉素的半合成类似物。Amikacin sulfate 具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。Amikacin sulfate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin sulfate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。

体外研究

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides , Mycobacterium avium-intracellulare , and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi ). Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD 50 value of 453 μM.

体内研究

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo. Animal Model: Male Fischer 344 rats (40-50-day-old) Dosage: 320 mg/kg Administration: Subcutaneous injection; daily; for 10 days Result: Induced hearing loss in rats.

Animal Model:

Male Fischer 344 rats (40-50-day-old)

Dosage:

320 mg/kg

Administration:

Subcutaneous injection; daily; for 10 days

Result:

Induced hearing loss in rats.

用途 

抗感染药，用于治疗敏感菌所致尿路感染、败血症、皮肤感染、骨与关节感染、肺炎及下呼吸道感染等

WGK Germany 

2

RTECS号

WK1961200