头孢西丁酸

中文名称:

头孢西丁酸

中文同义词:

头孢西丁;3-氨基甲酰基氧甲基-7-甲氧基-7-(2-噻吩乙酰胺基)-8-氧代-5-硫-1-杂氮双环[4.2.0]辛-2-烯-2-甲酸;头孢西丁 USP;噻吩甲氧头孢菌素,甲氧头霉噻吩,美福仙;(6R,7S)-3-[(氨基甲酰氧基)甲基]-7-甲氧基-8-氧代-7-[2-(噻吩-2-基)乙酰氨基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸;头孢西汀;CEFOXITIN 头孢西丁;原料药头孢西丁

英文名称:

Cefoxitin

英文同义词:

Cefoxitin【(6R-cis)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid】;(6r-cis)-ethyl)-7-methoxy-8-oxo-7-((2-thienylacetyl)amino);cephoxitin;cfx;CEFOXITIN;Mefoxin;CEFOXITIN ACID;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7S)-

CAS号:

35607-66-0

分子式:

C16H17N3O7S2

分子量:

427.45

EINECS号:

252-641-2

相关类别:

中间体;医药化工类;添加剂;对照品-杂质对照品;医药中间体;抗生素;Pharmaceutical intermediate;Pharmaceutical raw material;医药标准品;原料药;化学试剂

Mol文件:

35607-66-0.mol

 

 

熔点 

149-150℃

沸点 

843℃

密度 

1.4441 (rough estimate)

折射率 

1.6390 (estimate)

RTECS号

XI0386500

闪点 

>110°(230°F)

酸度系数(pKa)

2.2(at 25℃)

水溶解性 

Predicted solubility in water is less than 0.2mg/ml

CAS 数据库

35607-66-0(CAS DataBase Reference)

EPA化学物质信息

Cefoxitin (35607-66-0)

生物活性

Cefoxitin是一种β-内酰胺、头孢菌素抗生素，具有杀菌活性。

靶点

Antibiotic

体外研究

Cefoxitin has good activity against Gram-positive bacteria. The MICs for several Gram-positive pathogens are in the range of 1-6 μg/mL. Cefoxitin exhibits high efficacy killing B. burgdorferi at concentration of 1.25 µM/mL.

体内研究

Cefoxitin (20 mg/kg; i.p.; daily; for 5 days) effectively kills B. burgdorferi in C3H/HeN mice model. Animal Model: Four-week-old female C3H/HeN mice Dosage: 20 mg/kg Administration: Intraperitoneal injection, daily, for five consecutive days Result: Had shown high efficacy killing B. burgdorferi in vivo.

Animal Model:

Four-week-old female C3H/HeN mice

Dosage:

20 mg/kg

Administration:

Intraperitoneal injection, daily, for five consecutive days

Result:

Had shown high efficacy killing B. burgdorferi in vivo.

类别

有毒物质

毒性分级

低毒

急性毒性

静脉-大鼠 LD50: 8580 毫克/公斤; 静脉-小鼠 LD50: 4970 毫克/公斤

可燃性危险特性

热分解排出有毒氮氧化物, 硫氧化物烟雾

储运特性

库房低温通风干燥

灭火剂

水,二氧化碳, 泡沫, 干粉

危险品运输编号 

3077

HazardClass 

9

PackingGroup 

III

海关编码 

30032013