硫酸卡那霉素

中文名称:

硫酸卡那霉素

中文同义词:

硫酸卡那霉素,细胞培养级99%;硫酸卡那霉素USP99%;單硫酸素;硫酸卡那霉素;卡那霉素硫酸盐 标准品;KANAMYCIN MONO SULFATE 硫酸卡那霉素 标准品;单硫酸卡那霉素[本批大概19.…];卡那霉素(KAN)

英文名称:

Kanamycin sulfate

英文同义词:

KANAMYCIN MONOSULFATE GAMMA-IRRADIATED*M OLECULAR BI;KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETIC;KANAMYCIN MONOSULFATE, BPC GRADE;KANAMYCIN SOLUTION 50MG/ML (STERILE*FILT ERED) CELL;KANAMYCIN SULFATE USP(CRM STANDARD);KANAMYCIN SULFATE USP 99%;KANAMYCIN SULFATE, MOLECULAR BIOLOGY GRADE;KANAMYCIN SULFATE CELL CULTURE GRADE 99%

CAS号:

25389-94-0

分子式:

C18H38N4O15S

分子量:

582.58

EINECS号:

246-933-9

相关类别:

抗生素;抗生素类;医药 氨基核糖类抗生素;氨基核糖类抗生素;生命科学标准品;生化试剂;原料药;高纯生化试剂;原料药，抗生素类;分析标准品;氨基糖苷类抗生素;原料;小分子抑制剂;小分子抑制剂，天然产物;细胞生物;医药原料药-科研原料;兽药原料药;对照品;原料中间体-原料药;试剂;医用原料;医药原料;医药原料药;化学试剂;Aminoglycosides (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Peptide Synthesis/Antibiotics;Amines;Intermediates Fine Chemicals;Oligosaccharides;Pharmaceuticals;API;KANTREX;antibiotic;Inhibitors;中药对照品;化学原料;医药、农药及染料中间体;畜禽试剂

Mol文件:

25389-94-0.mol

熔点 

250°C

比旋光度 

+112～+123°(D/20℃)(c=1,H2O)(calculated on the dried basis)

密度 

1.3619 (rough estimate)

折射率 

117.5 ° (C=1, H2O)

储存条件 

2-8°C

溶解度 

H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.

形态

powder

颜色

white to off-white

酸碱指示剂变色ph值范围

6.5 - 8.5 (1% solution)

水溶解性 

Soluble in water at 10mg/ml

Merck 

14,5281

InChIKey

OOYGSFOGFJDDHP-KMCOLRRFSA-N

生物活性

Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan)是一种氨基糖苷类化合物，口服有效，可静脉注射，肌肉注射，广泛应用于感染。

体外研究

Kanamycin sulfate at the concentration above 0.0025% has a significant inhibition on the growth of B. bifidum and has no influence on the other four probiotics at incubation 12 h or 24 h. The optimum selective concentration of kanamycin sulfate in MRS media is 0.005% for selective enumeration of B.bifidum.

体内研究

The neurons damage of the DCN caused by kanamycin (500 mg/kg/day) is reversible and autophagy is upregulated in the neurotoxic course of kanamycin on DCN through JNK1-mediated phosphorylation of Bcl-2 pathway in rats. The serum BUN and Cr levels are both increased at the 1st day after the period of kanamycin administration. The neurons expressing LC3 are increased at 1, 7 and 14 days after kanamycin administration in comparison to the control group. Kanamycin treatment results in the increase of autophagy in a time-dependent manner. Kanamycin sulfate (5 mg/kg) and sodium ampicillin (10 mg/kg) administered intramuscularly (i.m.) separately, and then together, to five pony mares, and the ampicillin concentration exceeds 5 mg/mL in inflamed synovial fluid for some 2.5 h after injection, and kanamycin sulfate concentration exceeds 2 mg/mL for 7 h in the pony.

用途 

用于治疗食道炎、胃窦炎、细菌性痢疾及消化道感染

用途 

生化研究

用途 

生物技术的应用，以抑制蛋白质的合成。用于转化细胞用卡那霉素B（neoR，KanR表型）抗性基因作为选择剂。

危险品标志 

T

危险类别码 

61

安全说明 

22-24/25-45-53

WGK Germany 

3

RTECS号

NZ3225030

海关编码 

29419020

毒性

LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zeltser)